Abstract
Although earlier investigations of the mammalian metabolism of flavonoid compounds were largely concerned with the identification of their urinary metabolites (cf. De Eds, 1968), more recent studies have centred on the role of the intestinal microflora in the catabolism of flavonoid molecules, on the significance of the biliary-enteric route of excretion and on the disposition of flavonoids in mammalian tissues following oral and parenteral administration. Additionally the introduction of chemically modified flavonoids and of synthetic phenylchro-mones as therapeutic agents has promoted metabolic and pharmacokinetic investigations on compounds showing close structural relationships with the naturally occurring flavonoids.
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References
Alworth, W. L., Dang, C. C., Ching, L. M. and Viswanathan, T. (1980), Xenobiotica 10, 395.
Balant, L., Burki, B., Wermeille, M. and Golden, G. (1979), Arzneimittel-Forsch. 29, 1758.
Barrow, A. and Griffiths, L. A. (1971), Biochem. J. 125, 24p.
Barrow, A. and Griffiths, L. A. (1972), Xenobiotica 2, 575.
Barrow, A. and Griffiths, L. A. (1974a), Xenobiotica 4, 1.
Barrow, A. and Griffiths, L. A. (1974b), Xenobiotica 4, 743.
Batterham, T. J., Hart, N. K., Lamberton, J. A. and Braden, A. W. H. (1965), Nature (London) 206, 509
Batterham, T. J., Shutt, D. A., Hart, N. K., Braden, A. W. H. and Tweeddale, H. J. (1971), Aust. J. Agric. Res. 22, 131.
Baumann, J. and Von Bruchhausen, F. (1979), Naunyn-Schmiedeberg’s Arch. Pharmacol. 306, 85.
Bjeldanes, L. F. and Chang, G. W. (1977), Science 197, 577.
Boobis, A. R., Nebert, D. W. and Felton, J. S. (1977), Mol. Pharmacol. 13, 259.
Booth, A. N., Murray, C. W., De Eds, F. and Jones, F. T. (1955), Fed. Proc. Fed. Am. Soc. Exp. Biol. 14, 321.
Booth, A. N., Murray, C. W., Jones, F. T. and De Eds, F. (1956), J. Biol. Chem. 223, 251.
Booth, A. N., Emerson, A. H., Jones, F. T. and De Eds, F. (1957), J. Biol. Chem. 229, 51.
Booth, A. N., Jones, F. T. and De Eds, F. (1958a) J. Biol. Chem. 230, 661.
Booth, A. N., Jones, F. T. and De Eds, F. (1958b) J. Biol. Chem. 233, 280.
Brown, J. P. (1980), Mutat. Res. 75, 243.
Brown, J. P. and Dietrich, P. S. (1979), Mutat. Res. 66, 223.
Brown, J. P., Crosby, G. A., Du Bois, G. E., Enderlin, F. E., Hale, R. L. and Wingard, R. E. (1978), J. Agric. Food Chem. 26, 1418.
Bülles, H., Bülles, J., Krumbiegel, G., Mennicke, W. H. and Nitz, D. (1975), Arzneimittel-Forsch. 25, 902.
Buset, H. and Scheline, R. R. (1979), Biomed. Mass Spectrom. 6, 212.
Buset, H. and Scheline, R. R. (1980), Acta Pharm. Suec. 17, 157.
Carpenedo, F., Bortignon, D., Bruni, A. and Santi, R. (1969), Biochem. Pharmacol. 18, 1495
Cheng, K. J., Krishnamurty, H. G., Jones, G. A. and Simpson, F. J. (1971), Can. J. Microbiol. 17, 129.
Claveau, P. and Masquelier, J. (1966), Can. J. Pharm. Sci. 1, 74.
Courbat, P., Favre, J., Guerne, R. and Uhlmann, G. (1966a), Helv. Chim. Acta 49, 1202
Courbât P., Uhlmann, G. and Guerne, R. (1966b) Helv. Chim. Acta 49, 1420
Das, N. P. (1969), Biochim. Biophys. Acta 177, 668.
Das, N. P. (1971), Biochem. Pharmacol. 20, 3435
Das, N. P. (1974), Drug Metab. Dispos. 2, 209.
Das, N. P. and Griffiths, L. A. (1966), Biochem. J. 98, 488.
Das, N. P. and Griffiths, L. A. (1968), Biochem. J. 110, 449.
Das, N. P. and Griffiths, L. A. (1969), Biochem. J. 115, 831.
Das, N. P. and Sothy, S. P. (1971), Biochem. J. 125, 417.
Das, N. P., Scott, K. N. and Duncan, J. H. (1973), Biochem. J. 136, 903.
De Eds, F. (1968). In Comprehensive Biochemistry (ed. Florkin), Vol. 20, Elsevier, London.
Diamond, L. and Gelboin, H. V. (1969), Science 166, 1023
Fang, W-F. and Strobel, H. W. (1978), Cancer Res. 38, 2939
Förster, H. (1975). In Topics in Flavonoid Chemistry and Biochemistry(eds. L. Farkas, M. Garbor and F. Kallay), Elsevier, Amsterdam, p. 257.
Förster, H. (1977). In Flavonoids and Bioflavonoids (eds. L. Farkas, M. Gabor and F. Kallay), Elsevier, Amsterdam, p. 333.
Förster, H. (1978). In O-(β-Hydroxyethyl) rutoside. Experimentelle und Klinische Ergebnisse (eds W. Voelter and G. Jung), Springer-Verlag, Berlin, p. 43.
Förster, H., Bruhn, V. and Hoos I. (1972), Arzneimittel-Forsch. 22, 1312.
Gabor, M. (1975), Abriss der Pharmakologie von Flavonoiden, Akademiai Kiado, Budapest, p. 24.
Giles, A. R. and Gumma, A. (1973), Arzneimittel-Forsch. 23, 98.
Griffiths, L. A. (1962), Nature (London) 194, 869.
Griffiths, L. A. (1964), Biochem. J. 92, 173.
Griffiths, L. A. (1970), Experientia 26, 723.
Griffiths, L. A. (1975). In Topics in Flavonoid Chemistry and Biochemistry (eds L. Farkas, M. Garbor and F. Kallay), Elsevier, Amsterdam, p. 201.
Griffiths, L. A. and Barrow, A. (1972), Biochem. J. 130, 1161
Griffiths, L. A. and Hackett, A. M. (1977). In Flavonoids and Bioflavonoids (eds. L. Farkas, M. Gabor and F. Kallay), Elsevier, Amsterdam, p. 325.
Griffiths, L. A. and Hackett, A. M. (1978), Abstr. 7th Int. Congr. Pharmacol, 833.
Griffiths, L. A. and Smith, G. E. (1972a), Biochem. J. 128, 901.
Griffiths, L. A. and Smith, G. E. (1972b), Biochem. J. 130, 141.
Griffiths, L. A., Hackett, A. M., Shaw, I. C. and Brown, S. (1980). In Recent Developments in Mass Spectrometry in Biochemistry, Medicine and Environmental Research (ed. A. Frigerio), Elsevier, Amsterdam, p. 91.
Gugler, R. and Dengler, H. J. (1973), Naunyn-Schmiedeberg’s Arch. Pharmacol. 216, 223.
Gugler, R., Leschnik, M. and Dengler, H. J. (1975), Eur. J. Clin. Pharmacol. 9, 229.
Hackett, A. M. and Griffiths, L. A. (1977a), Xenobiotica 7, 641.
Hackett, A. M. and Griffiths, L. A. (1977b), Experientia 33, 161.
Hackett, A. M. and Griffiths, L. A. (1979), Eur. J. Drug Metab. 4, 207.
Hackett, A. M. and Griffiths, L. A. (1981), Drug. Metab. Dispos. 9, 54.
Hackett, A. M., Marsh, I., Barrow, A. and Griffiths, L. A. (1979), Xenobiotica 9, 491.
Hackett, A. M., Griffiths, L. A., Luyckx, A. S. and van Cauwenberge, H. (1976), Arzneimittel-Forsch. 26, 925.
Hardigree, A. A. and Epler, J. L. (1978), Mutat. Res. 58, 231.
Harmand, M. F. and Blanquet, P. (1978), Eur. J. Drug Me tab. 3, 31.
Hawksworth, G., Drasar, B. S. and Hill, M. J. (1971), J. Med. Microbiol. 4, 451.
Hems, R., Ross, B. D., Berry, M. N. and Krebs, H. A. (1966), Biochem. J. 101, 284.
Honohan, T., Hale, R. L., Brown, J. P. and Wingard, R. E. (1976), J. Agric. Food Chem. 24, 906.
Jeffrey, A. M., Knight, M. and Evans, W. C. (1969), J. Gen. Microbiol. 56, 1.
Jeffrey, A. M., Knight, M. and Evans, W. C. (1972a), Biochem. J. 130, 373.
Jeffrey, A. M., Jerina, D. M., Self, R. and Evans, W. C. (1972b), Biochem. J. 130, 383.
Jung, G., Ottnad, M. and Voelter, W. (1977), Eur. J. Drug Metab. 2, 131.
Kallianos, A. G., Petrakis, P. S. and Shetlar, M. R. (1959), Arch. Biochem. Biophys. 81, 430.
Krishnamurty, H. G., Cheng, K-J, Jones, G. A., Simpson, F. J. and Watkin, J. E. (1970), Can. J. Microbiol. 16, 759.
Kühnau, J. (1976), Wld. Rev. Nutr. Diet 24, 117.
Labow, R. S. and Layne, D. S. (1972), Biochem. J. 128, 491.
Laparra, J. and Michaud, J. (1973), C. R. Acad. Sci. Paris 276, 2847
Lietti, A., Cristoni, A. and Picci, M. (1976), Arzneimittel-Forsch. 26, 829.
MacGregor, J. T. and Jurd, L. (1978), Mutat. Res. 54, 297.
Marsh, C. A., Alexander, F. and Levvy, G. A. (1952), Nature (London) 170, 163.
Masquelier, J., Claveau, P. and Golse, J. (1965), Bull. Soc. Pharm. Bordeaux 104, 193.
Masri, M. S., Booth, A. N. and De Eds, F. (1959), Arch. Biochem. Biophys. 85, 284.
Masri, M. S., Booth, A. N. and De Eds, F. (1962), Biochim. Biophys. Acta 65, 495.
Mennicke, W. H., Lang, W. and Lorenz, D. (1979), Hepatology (Falk Foundation), 79, 411.
Mirkovitch, V., Robinson, J. W. L., Bel, F. and Gumma, A. (1973), Arzneimittel-Forsch. 23, 967.
Mori, S. and Noguchi, I. (1970), Arch. Biochem. Biophys. 139, 444.
Nakagawa, Y., Shetlar, M. R. and Wender, S. H. (1965), Biochim. Biophys. Acta 97, 233.
Nilsson, A., Hill, J. L. and Davies, H. L. (1967), Biochim. Biophys. Acta 148, 92.
Oshima, Y. and Watanabe, H. (1958), J. Biochem. (Tokyo) 45, 973.
Oshima, Y., Watanabe, H. and Isakari, S. (1958), J. Biochem. (Tokyo) 45, 861.
Oshima, Y., Watanabe, H. and Kuwazuka, S. (1960), Bull. Agric. Chem. Soc. (Jpn.) 24, 497.
Oustrin, J., Fauran, M. J. and Commanay, L. (1977), Arzneimittel-Forsch. 27, 1688
Pamukcu, A. M., Hatcher, J., Taguchi, H. and Bryan, G. T. (1980a), Proc. Am. Assoc. Cancer Res. 21, 74.
Pamukcu, A. M., Hatcher, J., Taguchi, H. and Bryan, G. T. (1980b), Cancer Res. 40, 3468
Paris, R. R. and Delaveau, P. (1977), Plant. Med. Phytother. 11, No. spec, 198.
Peter, H., Fisel, J. and Weisser, W. (1966), Arzneimittel-Forsch. 16, 719.
Petrakis, P. L., Kallianos, A. G., Wender, S. H. and Shetlar, M. R. (1959), Arch. Biochem, Biophys. 85, 264.
Pfeifer, K., Mehnert, N. and Hulsmann, N. (1970), Dte Gesundh- Wesen 25, 386.
Powell, G. M., Miller, J. J., Olavesen, A. H. and Curtis, C. G. (1974), Nature (London) 252, 234.
Ruckstuhl, M., Beretz, A., Anton, R. and Landry, Y. (1979), Biochem. Pharmacol. 28, 535.
Scheline, R. R. (1966), J. Pharm. Pharmacol. 18, 664.
Scheline, R. R. (1968a), Acta Pharmacol. Toxicol. 26, 189.
Scheline, R. R. (1968b), Acta Pharmacol. Toxicol. 26, 332.
Scheline, R. R. (1970), Biochim. Biophys. Acta 222, 228.
Scheline, R. R. (1978), Mammalian Metabolism of Plant Xenobiotics, Academic Press, London, p. 295.
Schultz, E., Engle, F. E. and Wood, J. M. (1974), Biochemistry 13, 1768
Schwabe, K-P. and Flohe, L. (1972), Hoppe-Seyler’s Z. Physiol. Chem. 353, 476.
Setnikar, I., Cova, A. and Magistretti, M. J. (1975), Arzneimittel-Forsch. 25, 1916
Shamrai, E. F. and Fedurov, V. V. (1967), Ukrayins’ki Biokhimichnyi Zhurnal 39, 83.
Shamrai, E. F. and Zaprometov, M. N. (1964), Biokhimiya 29, 595.
Shaw, I. C. and Griffiths, L. A. (1980), Xenobiotica 10, 905.
Shutt, D. A. and Braden, A. W. H. (1968), Aust. J. Agric. Res. 19, 545.
Simpson, F. J., Jones, G. A. and Wolin, E. A. (1969), Can. J. Microbiol. 15, 972.
Smith, R. L. (1973), The Excretory Function of Bile. Chapman and Hall, London.
Sugimura, T., Nagao, M., Matsushima, T., Yahagi, T., Seino, Y., Shirai, A., Sawamura, M., Natori, S., Yoshihira, K., Fukuoka, M. and Kuroyanagi, M. (1977), Proc. Jpn. Acad. Ser. B 53, 194.
Svardal, A., Buset, H. and Scheline, R. R. (1980), Acta Pharm. Suec. 18, 55.
Takacs, O. and Gabor, M. (1975). In Topics in Flavonoid Chemistry and Biochemistry (eds. L. Farkas, M. Gabor and F. Kallay), Elsevier, Amsterdam, p. 227.
Tamura, G., Gold, C., Ferro-Luzzi, A. and Ames, B. N. (1980), Proc. Natl. Acad. Sci. U.S.A. 77, 4961.
Tamemasa, O., Goto, R. and Ogura, S. (1976), Pharmacometrics (Japan), 12, 193.
Tan, H. S. I., Mowery, P. J., Ritschel, W. A. and Neu, C. (1978), J. Pharm. Sci. 67, 1142
Varma, S. D. and Kinoshita, J. H. (1976), Biochem. Pharmacol. 25, 2505
Varma, S. D., Mikuri, I. and Kinoshita, J. H. (1975), Science 188, 1215
Wattenberg, L. W., Page, M. A. and Leong, J. L. (1968), Cancer Res. 28, 934.
Wiebel, F. J. and Gelboin, H. V. (1975), Biochem. Pharmacol. 24, 1511
Wienert, V. and Gahlen, W. (1970), Hautarzt 21, 278.
Wurm, G. (1975), Dtsch. Apothek. Z. 115, 355.
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Griffiths, L.A. (1982). Mammalian Metabolism of Flavonoids. In: Harborne, J.B., Mabry, T.J. (eds) The Flavonoids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2915-0_12
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