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Evidence for a Site Specific Genomic Rearrangement in the slo Region of Streptococcus pyogenes

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Streptococci and the Host

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 418))

Abstract

Regulation of bacterial genes and operons in most cases occurs by regulatory molecules which modulate either transcription initiation or transcription progression. However, an increasing number of examples show that programmed or targeted DNA rearrangements can also alter gene expression (1–3). Here we present a case of a chromosomal rearrangement in the slo-has region of Streptococcus pyogenes which might affect expression of the slo gene.

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References

  1. Borst, P, and D.R. Graves (1987) Programmed gene rearrangements altering gene expression. Science 235:658 667.

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  2. Johnson, R.C. (1995) Site-specific recombinases and their interaction with DNA. In: DNA-Protein Structural Interactions (Edited by D.M.J. Lily), pp. 141-176. IRL Press

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  3. Nash, A.H. (1996) Site-specific recombination: Integration, excision, resolution, and inversion of defined DNA segments. In: Escherichia coli and Salmonella typhimurium; Cellular and Molecular Biology (Ed:), American Society for Microbiology.

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  4. Sambrook J., E.F. Fritsch, and T.E. Maniatis (1989) Molecular cloning: a laboratory manual, 2nd edition. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

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© 1997 Springer Science+Business Media New York

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Savic, D.J., Ferretti, J.J. (1997). Evidence for a Site Specific Genomic Rearrangement in the slo Region of Streptococcus pyogenes . In: Horaud, T., Bouvet, A., Leclercq, R., de Montclos, H., Sicard, M. (eds) Streptococci and the Host. Advances in Experimental Medicine and Biology, vol 418. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1825-3_231

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  • DOI: https://doi.org/10.1007/978-1-4899-1825-3_231

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1827-7

  • Online ISBN: 978-1-4899-1825-3

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