Skip to main content
SpringerLink
Log in

Serotonin Uptake Blockers and Voluntary Alcohol Consumption

A Review of Recent Studies

  • Chapter
Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 7))

Abstract

Previous research demonstrated that serotonin uptake blockers (e. g., zimeldine, sertraline, fluoxetine) reduce voluntary ethanol consumption in rats and humans. However, the mechanism of action of these compounds is not well understood. It has been suggested, for example, that serotonin uptake blockade interferes with the processes that mediate the reinforcement derived from ethanol ingestion. On the other hand, there is considerable experimental evidence that suggests that the effects on alcohol intake may be an expression of a more general inhibitory role that serotonin plays in consummatory behavior. This chapter presents evidence that suggests that serotonin uptake blockers may affect ethanol intake, in part via a reduction of food intake. Current issues concerning the central versus pheripheral mediation of these effects, receptor specificity, as well as alternate mechanisms of action are considered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Chick J: The social and clinical importance of intoxication, in Edwards G, Littleton J (eds): Pharamacological Treatments for Alcoholism. New York, Methuen, 1984.

    Google Scholar 

  2. Le Dain G: Final Report of the Commission of Inquiry into the Non-medical Use of Drugs. Ottawa, Information Canada, 1973.

    Google Scholar 

  3. Edwards G, Littleton J: Pharmacological Treatments for Alcoholism. New York, Methuen, 1984.

    Google Scholar 

  4. Naranjo CA, Sellers EM: Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  5. Edwards G: Drug treatments for drinking problems: Finding a way forward, Edwards G, Littleton J (eds): Pharmacological Treatments for Alcoholism. New York, Methuen, 1984.

    Google Scholar 

  6. Naranjo CA: Drug treatments for alcoholism: The need for innovation, in Naranjo, CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  7. Teeling-Smith G: Pharmacological treatments for alcohol problems as a challenge to pharmaceutical innovation, in Edwards G, Littleton J (eds): Pharmacological Treatments for Alcoholism. New York, Methuen, 1984.

    Google Scholar 

  8. Clare, A. The clinician’s needs and the patient’s needs, Edwards G, Littleton J (eds): Pharmacological Treatments for Alcoholism. New York, Methuen, 1984.

    Google Scholar 

  9. Hofmann FG: A Handbook on Drug and Alcohol Abuse. New York, Oxford University Press, 1983.

    Google Scholar 

  10. Fuller RK: A critical analysis of the efficacy and toxicity of the alcohol sensitising drugs, in Edwards G, Littleton J (eds): Pharmacological Treatments for Alcoholism. New York, Methuen, 1984.

    Google Scholar 

  11. Peachey JE, Annis H: New strategies for using the alcohol sensitizing drugs, in Naranjo, CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  12. Amit Z, Sutherland A: The relevance of recent animal studies for the development of treatment procedures for alcoholics. Drug Alc Depend 1: 3–13, 1975/76.

    CAS  Google Scholar 

  13. Rockman GE, Amit Z, Carr G, Brown Z, Ogren SO: Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats. I. Involvement of brain 5-hydroxytryptamine in the mediation of the positive reinforcing properties of ethanol. Arch Int Pharmacodyn Ther 241: 245–259, 1979.

    PubMed  CAS  Google Scholar 

  14. Rockman GE, Amit Z, Carr G, Ogren SO: Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockage in laboratory rats. II. Possible interaction with brain norepinephrine. Arch Int Pharmacodyn Ther 241: 260–265, 1979.

    PubMed  CAS  Google Scholar 

  15. Naranjo CA, Sellers EM, Roach CA, Woodley DV, Sanchez-Craig M, Sykora K: Zimelidine induced variations in ethanol intake in non-depressed heavy drinkers. Clin Pharmacol Ther 35: 374–381, 1984.

    PubMed  CAS  Google Scholar 

  16. Amit Z, Brown Z, Sutherland A, Rockman G, Gill K, Selvaggi N: Reduction in alcohol intake in humans as a function of treatment with zimeldine: Implications for treatment, in Naranjo CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  17. Weingartner H, Rudorfer MV, Buchsbaum MS, Linnoila M: Effects of serotonin on memory impairments produced by ethanol. Science 221: 472–473, 1983.

    PubMed  CAS  Google Scholar 

  18. Aberg A, Holmberg G: Preliminary clinical test of zimelidine (H102/09), a new 5-HT uptake inhibitor. Acta Psychiat Scand 59: 45, 1979.

    PubMed  CAS  Google Scholar 

  19. Naranjo CA, Sellers EM, Wu PH, Lawrin MO: Moderation of ethanol drinking: Role of enhanced serotonergic neurotransmission, in Naranjo CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  20. Amit Z, Sutherland A, Gill K, Ogren SO: Zimeldine: A review of its effects on ethanol consumption. Neurosci Biobehav Rev. 8: 35–54, 1984.

    PubMed  CAS  Google Scholar 

  21. Gill K, Amit Z, Ogren SO: The effects of zimeldine on voluntary ethanol consumption: Studies on the mechanism of action. Alcohol 2: 343–347, 1985.

    PubMed  CAS  Google Scholar 

  22. Blundell JE: Serotonin and appetite. Neuropharmacology 23: 1537–1551, 1984.

    PubMed  CAS  Google Scholar 

  23. Badawy A, Punjani NF, Evans M: Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity. Biochem J 178: 575–580, 1979.

    PubMed  CAS  Google Scholar 

  24. Hunt WA, Majchrowicz E: Studies of neurotransmitter interactions after acute and chronic ethanol administration. Pharmacol Biochem Behav 18: 371–374, 1983.

    PubMed  CAS  Google Scholar 

  25. Ahtee L, Eriksson K: 5-Hydroxytryptamine and 5-hydroxyindoleacetic acid content in brain of rat strains selected for their alcohol intake. Physiol Behav 8: 123–126, 1972.

    PubMed  CAS  Google Scholar 

  26. Geller I: Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat. Pharmacol Biochem Behav 1: 361–365, 1973.

    PubMed  CAS  Google Scholar 

  27. Myers RD, Veale WL: Alcohol preference in the rat: Reduction following depletion of brain serotonin. Science 160: 1469–1471, 1968.

    PubMed  CAS  Google Scholar 

  28. Veale WL, Myers RD: Decrease in ethanol intake in rats following administration of p-chlorophenylalanine. Neuropsychopharmacology 9: 317–326, 1970.

    CAS  Google Scholar 

  29. Stein JM, Wayner MJ, Tilson HA: The effect of p-chlorophenylalanine on the intake of ethanol and saccharin solutions. Pharmacol Biochem Behav 6: 117–122, 1977.

    PubMed  CAS  Google Scholar 

  30. Nachman M, Lester D, Le Magnen J: Alcohol aversion in the rat: Behavioral assessment of noxious drug effects. Science 168: 1244–1246, 1970.

    PubMed  CAS  Google Scholar 

  31. Holman RB, Hoyland V, Shillito EE: The failure of p-chlorophenylalanine to affect voluntary alcohol consumption in rats. Br J Pharmacol 53: 299–304, 1975.

    PubMed  CAS  Google Scholar 

  32. Ho AKS, Tsai CS, Chen R, Begleiter H, Kissin B: Experimental studies on alcoholism. I. Increased in alcohol preference by 5,6-dihydroxytryptamine and brain acetylcholine. Psychopharmacologia 40: 101–107, 1974.

    PubMed  CAS  Google Scholar 

  33. Myers RD, Melchior CL: Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. Res Commum Chem Pathol Pharmacol 10: 363–378, 1975.

    CAS  Google Scholar 

  34. Kiianmaa K: Alcohol intake in the rat after lowering brain 5-hydroxytryptamine content by electrolytic midbrain raphe lesions, 5,6-dihydroxytryptamine or p-chlorophenylalanine. Med Biol 54: 203–209, 1976.

    PubMed  CAS  Google Scholar 

  35. Melchior C, Myers, RD: Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles. Pharmacol Biochem Behav 5: 63–72, 1976.

    PubMed  CAS  Google Scholar 

  36. Geller I, Hartmann RJ, Messiha FS: Effects of cinanserin, a serotonin antagonist on ethanol preference in the rat. Proc W Pharm Soc 18: 141–145, 1975.

    CAS  Google Scholar 

  37. Zabik JE, Binkerd K, Roache JD: Serotonin and ethanol aversion in the rat, in Naranjo CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  38. Hill SY: Intraventricular injection of 5-hydroxytryptamine and alcohol consumption in rats. Biol Psychiatry 8: 151–158, 1974.

    PubMed  CAS  Google Scholar 

  39. Myers RD, Martin GE: The role of cerebral serotonin in the ethanol preference of animals. Ann NY Acad Sci 215: 135–144, 1973.

    PubMed  CAS  Google Scholar 

  40. Zabik JE, Liao S, Jeffreys M, Maickel RP: The effects of DL-5-hydroxytryptophan on ethanol consumption by rats. Res Commum Chem Pathol Pharmacol 20: 69–78, 1978.

    CAS  Google Scholar 

  41. Geller I, Hartmann RJ, Messiha FS: Blockade of 5-hydroxytryptophan reduction of ethanol drinking with the decarboxylase inhibitor RO4-4602, N-1-DL-seryl-N-2-2,3,4-tri-hydroxybenzyl hydrazine hydrochloride. Pharmacol Biochem Behav 15: 871–874, 1981.

    PubMed  CAS  Google Scholar 

  42. Meek J, Fuxe K, Anden NE: Effects of antidepressant drugs of the imipramine type on central 5-hydroxytryptamine neurotransmission. Eur J Pharmacol 9: 325–332, 1970.

    PubMed  CAS  Google Scholar 

  43. Ogren SO, Lundstrom J, Moore G: Zimelidine pharmacology, pharmacokinetics, and clinical response, in Burrows GD, Norman T (eds): Psychotropic Drugs. New York, Marcel Dekker, 1981.

    Google Scholar 

  44. Ogren SO, Ross SB, Hall H, Holm AC, Renyi AL: The pharmacology of zimelidine: A 5-HT selective reuptake inhibitor. Acta Psychiat Scand, Suppl 290, 63: 127–151, 1981.

    Google Scholar 

  45. Pawlowski L, Mazela H: Norzimelidine, a metabolite of a highly selective 5-hydroxytryptamine uptake inhibitor, can inhibit the uptake of noradrenaline in vivo. J Pharm Pharmacol 36: 855–858, 1984.

    PubMed  CAS  Google Scholar 

  46. Ross SB, Renyi AL: Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)-and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)allylamines and their secondary analogues. Neuropharmacology 16: 57–63, 1977.

    PubMed  CAS  Google Scholar 

  47. Brown Z, Amit Z, Sutherland A, Rockman G, Selvaggi N, Ogren SO: An examination of possible interactions between zimelidine, a serotonin uptake inhibitor, and ethanol ingested conjointly in human subjects. Neurosci Lett 27: 351–355, 1981.

    PubMed  CAS  Google Scholar 

  48. Cott, JM, Ogren SO: Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice. J Neural Trans 48: 223–240, 1980.

    CAS  Google Scholar 

  49. Scott DB, Fagen D, Tiplady B: Effects of amitriptyline and zimelidine in combination with ethanol. Psychopharmacologia 76: 209–211, 1982.

    CAS  Google Scholar 

  50. Seppala T, Stromberg C, Bergman I: Effects of zimelidine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol: A placebo controlled crossover study. Eur J Clin Pharmacol 27: 181–190, 1984.

    PubMed  CAS  Google Scholar 

  51. Naranjo CA, Sellers EM, Kaplan HL, Hamilton C, Khouw V: Acute kinetic and dynamic interactions of zimelidine with ethanol. Clin Pharmacol Ther 36: 654–660, 1984.

    PubMed  CAS  Google Scholar 

  52. Rockman GE, Amit Z, Brown Z, Bourgue C, Ogren SO: An investigation of the mechanisms of action of 5-hydroxytryptamine in the suppression of ethanol intake. Neuropharmacology 21: 341–347, 1982.

    PubMed  CAS  Google Scholar 

  53. Daoust M, Saligaut C, Chadelaud M, Chretien P, Moore N, Boismare F: Attenuation by antidepressant drugs of alcohol intake in rats. Alcohol 1: 379–383, 1984.

    PubMed  CAS  Google Scholar 

  54. Gill K, Filion Y, Amit Z: A further examination of the effects of sertraline on voluntary ethanol consumption. Alcohol, in press, 1988.

    Google Scholar 

  55. Le Bourhis B, Uzan A, Aufrere G, LeFur G: Effects of Indalpin, a specific 5-HT uptake inhibitor, on the ethanol behavioral dependence and on the voluntary ethanol consumption in rat. Ann Pharmaceut Fran 39: 11–20, 1981.

    Google Scholar 

  56. Murphy JM, Waller MB, Gatto CJ, McBride WJ, Lumeng L, Li T-K: Monoamine uptake inhibitors attenuate ethanol intake in alcohol-preferring (P) rats. Alcohol 2: 349–352, 1985.

    PubMed  CAS  Google Scholar 

  57. Rockman, GE, Amit Z, Bourgue C, Brown Z, Ogren SO: Reduction of voluntary morphine consumption following treatment with zimelidine. Arch Int Pharmacodyn Ther 244: 123–129, 1980.

    PubMed  CAS  Google Scholar 

  58. Ronnback L, Zeuchner L, Rosengren A, Wronski A, Ogren SO: Decreased morphine intake by opiate addicted rats administered zimelidine—a 5-HT uptake inhibitor. Psychopharmacology 82: 30–35, 1984.

    PubMed  CAS  Google Scholar 

  59. Fitzsimmon J, LeMagnen J: Eating as a regulatory control of drinking in the rat. J Comp Physiol Psych 67: 273–283, 1969.

    Google Scholar 

  60. Hoebel BG, Zelman FP, Trulson ME, MacKenzie RG, DuCret RP, Norelli C: Differential effects of p-chlorophenylalanine and 5,7-dihydroxytryptamine on feeding in rats. Ann NY Acad Sci 305: 591–594, 1978.

    Google Scholar 

  61. Saller CF, Stricker EM: Hyperphagia and increased growth in rats after intraventricular 5,7-dihydroxytryptamine. Science 192: 365–387, 1976.

    Google Scholar 

  62. Hoebel BG: Pharmacological control of feeding. Ann Rev Pharmacol Toxicol 17: 605–621, 1977.

    CAS  Google Scholar 

  63. Barrett AM, McSharry L: Inhibition of drug-induced anorexia in rats by methysergide. J Pharm Pharmacol 27: 889–895, 1975.

    PubMed  CAS  Google Scholar 

  64. Blundell JE, Latham CJ: Pharmacological manipulation of feeding behavior: Possible influences of serotonin and dopamine on food intake, in Garattini S, Samanin R (eds): Central Mechanisms of Anorectic Drugs. New York, Raven Press, 1978.

    Google Scholar 

  65. Goudie AJ, Thornton EW, Wheeler TJ: Effects of Lilly 110140, a specific inhibitor of 5-hydroxytryptamine uptake, on food intake and on 5-hydroxytryptophan-induced anorexia: Evidence for serotoninergic inhibition of feeding. J Pharm Pharmacol 28: 318–320, 1976.

    PubMed  CAS  Google Scholar 

  66. Samanin R, Mennini T, Garattini S: Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain. Progress: Neuropsychopharmacol 4: 363–369, 1980.

    CAS  Google Scholar 

  67. Gottfies CG: Influence of depression and anti-depressants on weight. Acta Psychiatr Scand Suppl. 290, 63: 353–356, 1981.

    Google Scholar 

  68. Simpson RJ, Lawton DJ, Watt MH, Tiplady B: Effects of zimelidine, a new antidepressant, on appetite and body weight. Br J Clin Pharmacol 11: 96–98, 1981.

    PubMed  CAS  Google Scholar 

  69. Sugrue MF, Charleton KG, Mireylees SE, McIndewar I: Drug-induced anorexia and monoamine reuptake inhibition, Garattini S, Samanin R (eds): Central Mechanisms of Anorectic Drugs. New York, Raven Press, 1978.

    Google Scholar 

  70. Gill K, Amit Z: Effects of serotonin uptake blockade on food, water and ethanol consumption in rats. Alc Clin Exp Res 11: 444–449, 1987.

    CAS  Google Scholar 

  71. Kraly, FS: Physiology of drinking elicited by eating. Psych Rev 91: 478–490, 1984.

    CAS  Google Scholar 

  72. Carter RB, Dykstra LA, Leander JD, Appel JB: Role of peripheral mechanisms in the behavioral effects of 5-hydroxytryptophan. Pharmacol Biochem Behav 9: 249–253, 1978.

    PubMed  CAS  Google Scholar 

  73. Blundell JE, Latham CJ: Behavioural pharmacology of feeding, in Silverstone T (ed): Drugs and Appetite. London, Academic Press, 1982.

    Google Scholar 

  74. Gill K, Mori M, Remu K, Amit Z: An examination of the effects of the serotonin uptake blocker, zimeldine, on feeding and drinking behavior in rats. Manuscript in preparation.

    Google Scholar 

  75. Fuxe K, Ogren SO, Benfenati F, Agnati LF, in Usdin E (ed): Frontiers in Biochemical and Pharmacological Research in Depression, New York, Raven Press, 1984.

    Google Scholar 

  76. De Montigny C, Blier P: Effects of acute and repeated administration of antidepressant serotonin uptake blockers, in Mendlewicz J, Van Praag HM (eds): Advances in Biological Psychiatry, Vol. 14. Basel, Karger, 1984.

    Google Scholar 

  77. Zabik JE, Roache JD: 5-Hydroxytryptophan-induced conditioned taste aversion to ethanol in the rat. Pharmacol Biochem Behav 18: 785–790, 1983.

    PubMed  CAS  Google Scholar 

  78. Gill K, Shatz K, Amit Z, Ogren SO: Conditioned taste aversion to ethanol induced by zimeldine. Pharmacol Biochem Behav 24: 463–468, 1986.

    PubMed  CAS  Google Scholar 

  79. Carter RB, Appel JB: Blockade of the behavioral effects of 5-HTP by the decarboxylase inhibitor RO4-4602. Pharmacol Biochem Behav 4: 407–409, 1976.

    PubMed  CAS  Google Scholar 

  80. Fletcher PJ, Burton MJ: Effects of manipulations of peripheral serotonin on feeding and drinking in the rat. Pharmacol Biochem Behav 20: 835–840, 1984.

    PubMed  CAS  Google Scholar 

  81. Fletcher PJ, Burton MJ: Microstructural analysis of the anorectic action of peripherally administered 5-HT. Pharmacol Biochem Behav 24: 1133–1136, 1986.

    PubMed  CAS  Google Scholar 

  82. Clineschmidt BV: 5,6-Dihydroxytryptamine: Suppression of anorexigenic effect of fenfluramine Eur J Pharmacol 24: 405–409, 1973.

    PubMed  CAS  Google Scholar 

  83. Hollister AS, Ervin GN, Cooper BR, Breese G: The roles of monoamine neural systems in the anorexia induced by (+)-amphetamine and related compounds. Neuropharmacology 14: 715–723, 1975.

    PubMed  CAS  Google Scholar 

  84. Samanin R, Ghezzi D, Valzelli L, Garattini S: The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine. Eur J Pharmacol 19: 318–322, 1972.

    PubMed  CAS  Google Scholar 

  85. Davies RF, Rossi J, Panksepp J, Bean NJ, Zolovick AJ: Fenfluramine anorexia: A peripheral locus of action. Physiol Behav 30: 723–730, 1983.

    PubMed  CAS  Google Scholar 

  86. Sugrue MF, Goodlet I, McIndewar I: Failure of depletion of rat brain 5-hydroxytryptamine to alter fenfluramine-induced anorexia. J Pharm Pharmacol 27: 950–953, 1975.

    PubMed  CAS  Google Scholar 

  87. Ervin GN, Carter RB, Webster EL, Moore SI, Cooper BR: Evidence that taste aversion learning induced by 1-5-hydroxytryptophan is mediated peripherally. Pharmacol Biochem Behav 20: 799–902, 1984.

    PubMed  CAS  Google Scholar 

  88. Cooper SJ, Jackson A, Morgan R, Carter R: Evidence for opiate receptor involvement in the consumption of a high palatibility diet in non-deprived rats. Neuropeptides 5: 345–348, 1985.

    PubMed  CAS  Google Scholar 

  89. Kirkham TC, Barber DJ, Heath RW, Cooper SJ: Differential effects of CGS 8216 and naltrexone on ingestional behavior. Pharmacol Biochem Behav 26: 145–151, 1987.

    PubMed  CAS  Google Scholar 

  90. Levine AS, Murray SS, Kneip J, Grace M, Morley JE: Flavor enhances the antidipsogenic effect of naloxone. Physiol Behav 28: 23–25, 1982.

    PubMed  CAS  Google Scholar 

  91. Montgomery AMJ, Burton MJ: Effects of peripheral 5-HT on consumption of flavoured solutions. Psychopharmacology 88: 262–266, 1986.

    PubMed  CAS  Google Scholar 

  92. Leander JD: Fluoxetine suppresses palatability-induced ingestion. Psychopharmacology 91: 285–287, 1987.

    PubMed  CAS  Google Scholar 

  93. Messing RB, Pettibone DJ, Kaufman N, Lytle LD: Behavioral effects of serotonin neurotoxins: An overview. Ann NY Acad Sci 305: 480–496, 1978.

    PubMed  CAS  Google Scholar 

  94. Smith FL, Yu DS, Smith DG, Leccese AP, Lyness WH: Dietary tryptophan supplements attenuate amphetamine self-administration in the rat. Pharmacol Biochem Behav 25: 849–855, 1986.

    PubMed  CAS  Google Scholar 

  95. Lecesse AP, Lyness WH: The effects of putative 5-hydroxytryptamine receptor active agents on d-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions. Brain Res 303: 153–162, 1984.

    Google Scholar 

  96. Trulson ME, Jacobs BL: Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal. Brain Res 163: 135–150, 1979.

    PubMed  CAS  Google Scholar 

  97. Stricker EM: Brain neurochemistry and the control of food intake, in Satinoff E, Teitelbaum P (eds): Handbook of Behavioral Neurobiology, Vol 6. New York, Plenum Press, 1983.

    Google Scholar 

  98. Gershon SC, Baldessarini RJ: Motor effects of serotonin in the central nervous system. Life Sci 27: 1435–1451, 1980.

    Google Scholar 

  99. Li ETS, Anderson GH: 5-Hydroxytryptamine control of meal to meal composition chosen by rats. Fed Proc 42: 548, 1983.

    Google Scholar 

  100. Wurtman JJ, Wurtman RJ: Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats. Science 198: 1178–1180, 1977.

    PubMed  CAS  Google Scholar 

  101. Wurtman JJ, Wurtman RJ: Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats. Life Sci 24: 895–904, 1979.

    PubMed  CAS  Google Scholar 

  102. Stellar JR, Stellar E: The Neurobiology of Motivation and Reward. New York, Springer-Verlag, 1985.

    Google Scholar 

  103. Smith GP: The physiology of the meal, in Silverstone T (ed): Drugs and Appetite. London, Academic Press, 1982.

    Google Scholar 

  104. Nicolaidis S: Lateral hypothalamic control of metabolic factors related to feeding. Diabetologia 20: 426–434, 1981.

    PubMed  CAS  Google Scholar 

  105. Fantino M: Role of sensory input in the control of food intake. J Autonomie Nerv Sys 10: 347–358, 1984.

    CAS  Google Scholar 

  106. Waldbillig RJ, O’Callaghan M: Hormones and hedonics, cholecystokinin and taste: A possible behavioral mechanism of action. Physiol Behav 25: 25–30, 1980.

    PubMed  CAS  Google Scholar 

  107. Wise RA, Raptis L: Effects of pre-feeding on food-approach latency and food consumption speed in food deprived rats. Physiol Behav 35: 961–963, 1985.

    PubMed  CAS  Google Scholar 

  108. Strieker EM, McCann M: Visceral factors in the control of food intake. Brain Res Bull 14: 687–692, 1985.

    Google Scholar 

  109. Naranjo CA, Sellers EM, Sullivan JT, Woodley DV, Kadlec K, Sykora K: The serotonin uptake inhibitor Citalopram attenuates ethanol intake. Clin Pharm Therap 41: 266–274, 1987.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Studies in Behavioral Neurobiology, Psychology Department, Concordia University, Montreal, Quebec, H3G 1M8, Canada

    Kathryn Gill & Z. Amit

Authors
  1. Kathryn Gill
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Amit
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New York University School of Medicine, New York, New York, USA

    Marc Galanter

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gill, K., Amit, Z. (1989). Serotonin Uptake Blockers and Voluntary Alcohol Consumption. In: Galanter, M. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1678-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1678-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1680-8

  • Online ISBN: 978-1-4899-1678-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation