Abstract
Most vertebrates contain a single gene encoding for AChE, and alternative splicing gives rise to two catalytic subunits, H and T. H subunits form GPI-anchored dimers, whereas T subunits can occur as monomers, dimers and tetramers, which are dimers of disulfide-linked dimers. T subunits also associate with structural subunits (P and Q) to form membrane-anchored tetramers and asymmetric forms, in which one to three tetramers are attached to a collagen-like tail (1).
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Raves, M.L. et al. (1998). Quaternary Structure of Tetrameric Acetylcholinesterase. In: Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. (eds) Structure and Function of Cholinesterases and Related Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1540-5_97
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DOI: https://doi.org/10.1007/978-1-4899-1540-5_97
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