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Human AT1 Receptor Gene Regulation

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Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 396))

Abstract

The peptide hormone angiotensin II (AII), the biologically active component of the renin-angiotensin system, regulates a variety of physiological responses including fluid homeostasis, aldosterone production, renal function and contraction of vascular smooth muscle (1). In addition, AII has actions in the central nervous system (2) and may play a role in development (3). AII binds to specific receptors that mediate intracellular Ca2+ mobilization through stimulation of phospholipase C and production of inositol trisphosphate (4), activation of Ca2+ channels (5), and inhibition of adenylate cyclase through a pertussis toxin-sensitive G-protein (6). Given the diversity of AII-mediated events and the differential signal transduction mechanisms, it has been proposed that multiple AII receptor subtypes exist (1,7).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Benson Science Building, Brigham Young University, Provo, Utah, 84602, USA

    Baogen Su, Mickey M. Martin & Terry S. Elton

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  1. Baogen Su
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  2. Mickey M. Martin
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  3. Terry S. Elton
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada , M. Ian Phillips  & Colin Sumners ,  & 

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© 1996 Springer Science+Business Media New York

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Su, B., Martin, M.M., Elton, T.S. (1996). Human AT1 Receptor Gene Regulation. In: Raizada, M.K., Phillips, M.I., Sumners, C. (eds) Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors. Advances in Experimental Medicine and Biology, vol 396. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1376-0_2

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  • DOI: https://doi.org/10.1007/978-1-4899-1376-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1378-4

  • Online ISBN: 978-1-4899-1376-0

  • eBook Packages: Springer Book Archive

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