Abstract
CD40 is a 50kDA surface glycoprotein expressed predominantly on B cells, monocytes, dendritic cells, thymic epithelium and certain carcinomas.1–3 It is a member of the tumor necrosis factor receptor (TNFR) superfamily,4,5 a group of related type I transmembrane molecules which, in addition to CD40, includes both forms of TNFR, the low affinity nerve growth factor (NGF) receptor, CD27, CD30, OX40, 4-1BB, and Fas.6–9 Members of this family are characterized by the presence of multiple cysteine-rich repeats consisting of approximately 40 amino acids in the extracellular amino terminal domain.5 The average sequence homology between family members in the extracellular domain is around 25%.
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Spriggs, M.K. (1994). The Role of CD40 Ligand in Human Disease. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_25
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DOI: https://doi.org/10.1007/978-1-4899-0987-9_25
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