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Normal and Abnormal Regulation of Human B Cell Differentiation by a New Cytokine, BSF2/IL-6

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation II

Abstract

Antibody molecules play an essential role not only in protection against viral or bacterial infections, but also in the induction of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, and immediate-type hypersensitivity. Therefore, the study of the mechanism regulating the activation, proliferation and immunoglobulin secretion of B lymphocytes is essential for the normal and abnormal regulations in the antibody response.

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References

  1. T. Kishimoto, Factors affecting B-cell growth and differentiation, Ann. Rev. Immunol 3:133 (1985).

    Google Scholar 

  2. Y. Noma, T. Sideras, T. NAito, A. Bergstedt-Lindqvist, C. Azuma, E. Severinson, T. Tanabe, T. Kinashi, F. Matsuda, Y. Yaoita, and T. Honjo, Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature 319: 640 (1986).

    CAS  Google Scholar 

  3. F. Lee, T. Yokota, T. Otsuka, P. Meyerson, D. Villaret, N. Rocham, C. Smith, A. Zlotnick, and K. Arai, Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell and mast cell-stimulating activities. Proc. Natl. Acad. Sci.. USA 83:2061 (1986).

    Google Scholar 

  4. T. Kinashi, N. Harada, E. Severinson, R. Tanabe, P. Sideras, M. Konishi, C. Azuma, A. Tominaga, S. Bergstedt-Lindqvist, M. Takahashi, F. Matsuda, Y. Yaoita, K. Takatsu, and T. Honjo, Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor H. Nature 324: 70 (1986).

    CAS  Google Scholar 

  5. T. Hirano, K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatsu, S. Tsunasawa, F. Sakiyama, H. Matsui, Y. Takahara, T. Taniguchi, and T. Kishimoto, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73 (1986).

    CAS  Google Scholar 

  6. T. Kishimoto and T. Hirano, Molecular regulation of B lymphocyte response. Ann. Rev. Immunol 6:485 (1988).

    Google Scholar 

  7. J. Gauldie, C. Richards, D. Harnish, P. Lansdorp, and H. Baumann, Interferon ß2/BSF-2 shares identity with monocyte derived hepatocyte stimulating factor (HSF) and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci.. USA in press (1987).

    Google Scholar 

  8. T. Andus, T. Geiger, T. Hirano, H. Northoff, U. Ganter, J. Bauer, T. Kishimoto, and P.C. Heinrich, Recombinant human B cell stimulatory factor 2 (BSF-2/INFß2) regulates ß-fibrinogen and albumin mRNA levels in Fa0–9 cells. FEBS Lett 221:18 (1987)

    Google Scholar 

  9. K. Ikebuchi, G.G. Wong, S.C. Clark, J.N. Ihle, Y. Hirai, and M. Ogawa, Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci., USA 84:9035 (1987).

    Google Scholar 

  10. M. Lotz, F. Jirik, R. Kabouridis, C. Tsoukas, T. Hirano, T. Kishimoto, and D.A. Carson. BSF-2/IL-6 is a costimulant for human thymocytes and T lymphocytes. J. Exp. Med in press (1988).

    Google Scholar 

  11. A. Muraguchi, T. Kishimoto, Y. Miki, T. Kuritani, T. Kaieda, K. Yoshizaki, and Y. Yamamura, T cell-replacing factor (TRF)-induced IgG secretion in human B blastoid cell line and demonstration of acceptors for TRF. J. Immunol 127:412 (1981).

    Google Scholar 

  12. T. Hirano, T. Taga, N. Nakano, K. Yasukawa, S. Kashiwamura, K. Shimuzu, K. Nakajima, K.H. Pyun, and T. Kishimoto, Purification to homogeneity and characterization of human B cell differentiation factor (BCDF or BSFp-2). Proc. Natl. Acad. Sci., USA 82:5490 (1985).

    Google Scholar 

  13. T. Hirano, T. Matsuda, K. Hosoi, A. Okano, H. Matsui, and T. Kishimoto, Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2). Immunol Lett. 17: 41 (1988).

    PubMed  CAS  Google Scholar 

  14. A. Muraguchi, T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, and T. Kishimoto, The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med 167:332 (1988).

    Google Scholar 

  15. A. Zilberstein, R. Ruggieri, J.H. Korn, and M. Revel, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO Journal 5: 2529 (1986).

    CAS  Google Scholar 

  16. G. Haegeman, J. Content, G. Volckaert, R. Derynck, J. Tavernieir, and W. Fiers, Structural analysis of the sequence encoding for an inducible 26-kDa protein in human fibroblasts. Eur. J. Biochem 159: 625 (1986).

    Google Scholar 

  17. J. Weissenbach, Y. Chernajovsky, M. Zeevi, L. Shulman, H. Soreq, U. Nir, D. Wallach, M. Perricaudet, P. Tiollais, and M. Revel, Two interferon mRNA in human fibroblasts: In vitro translation and Escherichia coli cloning studies. Proc. Natl. Acad. Sci.. USA 77: 7152 (1980).

    Article  PubMed  CAS  Google Scholar 

  18. P. Poupart, P. Vandenabeele, S. Cayphas, J.V. Snick, G. Haegeman, V. Kruys, W. Fiers, and J. Content, B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-ß2, HPGF). EMBO J 6: 1219 (1987).

    Google Scholar 

  19. J. Van Damme, G. Opdenakker, R.J. Simpson, M.R. Rubira, S. Cayphas, A. Vink, A. Billiau, and J. Van Snick, Identification of the human 26-kD protein, interferon ß2 (IFN-ß2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J. Exp. Med 165:914 (1987).

    Google Scholar 

  20. M. Kawano, T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, H. Tanaka, A. Kuramoto, and T. Kishimoto, Autocrine generation and essential requirement of BSF-2/IL-6 for human multiple myelomas. Nature in press (1988).

    Google Scholar 

  21. K. Yasukawa, T. Hirano, Y. Watanabe, K. Muratani, T. Matsuda, S. Nakai, and T. Kishimoto, Structure and expression of human B cell stimulatory factor 2 (BSF-2) gene. EMBO J 6: 2939 (1987).

    CAS  Google Scholar 

  22. T. Hirano, T. Taga, K. Yasukawa, K. Nakajima, N. Nakano, F. Takatsuki, M. Shimuzu, A. Murashima, S. Tsunasawa, F. Sakiyama, and T. Kishimoto, Human B cell differentiation factor defined by an antipeptide antibody and its possible role in autoantibody production. Proc. Natl. Acad. Sci.. USA 84:228 (1987).

    Google Scholar 

  23. M.W. Nijsten, E.R. DeGroot, H.J. Duis, C.E. Hack, and L.A. Aarcen, Serum levels of interleukin 6 and acute phase response. Lancet ii: 921 (1987).

    Google Scholar 

  24. T. Taga, Y. Kawanishi, R.R. Hardy, T. Hirano, and T. Kishimoto, Receptors for B cell stimulatory factor 2 (BSF2): Quantitation, specificity, distribution and

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565, Japan

    Tadamitsu Kishimoto, Tetsuya Taga, Katsuhiko Yamasaki, Tadashi Matsuda, Bo Tang, Atsushi Muraguchi, Yasuhiro Horii, Sachiko Suematsu, Yuichi Hirata, Hideo Yawata, Masatoshi Shimizu, Michiaki Kawano & Toshio Hirano

Authors
  1. Tadamitsu Kishimoto
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  2. Tetsuya Taga
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  3. Katsuhiko Yamasaki
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  4. Tadashi Matsuda
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  5. Bo Tang
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  6. Atsushi Muraguchi
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  7. Yasuhiro Horii
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  8. Sachiko Suematsu
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  9. Yuichi Hirata
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  10. Hideo Yawata
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  11. Masatoshi Shimizu
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  12. Michiaki Kawano
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  13. Toshio Hirano
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Editor information

Editors and Affiliations

  1. Division of Basic and Clinical Immunology, University of California, Irvine, 92717, Irvine, California, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul

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© 1989 Springer Science+Business Media New York

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Kishimoto, T. et al. (1989). Normal and Abnormal Regulation of Human B Cell Differentiation by a New Cytokine, BSF2/IL-6. In: Gupta, S., Paul, W.E. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5803-0_16

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  • DOI: https://doi.org/10.1007/978-1-4757-5803-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5805-4

  • Online ISBN: 978-1-4757-5803-0

  • eBook Packages: Springer Book Archive

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