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Interaction of Yersinia with Host Cells

  • Chapter
Bacterial Invasion into Eukaryotic Cells

Part of the book series: Subcellular Biochemistry ((SCBI,volume 33))

Abstract

The Yersinia genus contains three species that are pathogenic for humans: Y. pestis, the agent of plague, and two enteropathogens, Y. pseudotuberculosis and Y. enterocolitica, that are generally acquired by ingestion of contaminated food. While Y. pseudotuberculosis is mainly a rodent pathogen, Y. enterocolitica is a frequent cause of disease in humans and provokes gastrointestinal syndromes of variable severity. After infection, secondary manifestations such as erythema nodosum and reactive arthritis can occur (for review, see Cover and Aber, 1989). Although these three pathogens have different entry routes and cause different diseases, they share a remarkable tropism for the lymphoid tissues of their host, where they are able to resist the non-specific immune defense mechanisms.

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References

  • Allaoui, A., Woestyn, S., Sluiters, C., and Cornelis, G.R., 1994, YscU, a Yersinia enterocolitica inner membrane protein involved in Yop secretion, J. Bacteriol. 176: 4534–4542.

    PubMed  CAS  Google Scholar 

  • Allaoui, A., Scheen, R., Lambert de Rouvroit, C.L., and Cornelis, G.R., 1995a, VirG, a Yersinia enterocolitica lipoprotein involved in Cat’ dependency, is related to ExsB of Pseudomonas aeruginosa, J. Bacteriol. 177: 4230–4237.

    PubMed  CAS  Google Scholar 

  • Allaoui, A., Schulte, R., and Cornelis, G.R., 1995b, Mutational analysis of the Yersinia enterocoliticia virC operon: characterization of yscE, F, G I, J, K required for Yop secretion and yscH encoding YopR, Mol. Microbiol. 18: 343–355.

    PubMed  CAS  Google Scholar 

  • Anderson, D.M., and Schneewind, O., 1997, A mRNA signal for the type III secretion of. Yop proteins by Yersinia enterocolitica, Science 278: 1140–1143.

    PubMed  CAS  Google Scholar 

  • Andersson, K., Carballeira, N., Magnusson, K.E., Persson, C., Stendahl, O., Wolf-Watz, H., and Hillman, M., 1996, YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis, Mol. Microbiol. 20: 1057–1069.

    PubMed  CAS  Google Scholar 

  • Autenrieth, I.B., and Firsching, R., 1996, Penetration of M cells and destruction of Peyer’s patches by Yersinia enterocolitica: an ultrastructural and histological study, J. Med. Microbiol. 44: 285–294.

    PubMed  CAS  Google Scholar 

  • Autenrieth, I.B., and Heesemann, J., 1992, In vivo neutralization of tumor necrosis factor-alpha and interferon-gamma abrogates resistance to Yersinia enterocolitica infection in mice, Med. Microbiol. Immunol. Berl. 181: 333–338.

    CAS  Google Scholar 

  • Balligand, G., Laroche, Y., and Cornelis, G., 1985, Genetic analysis of virulence plasmid from a serogroup 9 Yersinia enterocolitica strain: role of outer membrane protein P1 in resistance to human serum and autoagglutination, Infect. Immun. 48: 78 2786.

    Google Scholar 

  • Bergman, T., Erickson, K., Galyov, E.E., Persson, C., and Wolf-Watz, H., 1994, The lcrB (yscN/U) gene cluster of Yersinia pseudotuberculosis is involved in Yop secretion and shows high homology to the spa gene clusters of Shigella flexneri and Salmonella typhimurium, J. Bacteriol. 176: 2619–2626.

    PubMed  CAS  Google Scholar 

  • Beuscher, H.U., Rodel, E, Forsberg, A., and Rollinghoff, M., 1995, Bacterial evasion of host immune defense: Yersinia enterocolitica encodes a suppressor for tumor necrosis factor alpha expression, Infect. Immun. 63: 1270–1277.

    PubMed  CAS  Google Scholar 

  • Black, D.S., and Bliska, J.B., 1997, Identification of p130cB’ as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions, EMBO J. 16: 2730–2744.

    PubMed  CAS  Google Scholar 

  • Bliska, J.B., 1995, Crystal structure of the Yersinia tyrosine phosphatase, Trends. Microbiol. 3: 125–127.

    PubMed  CAS  Google Scholar 

  • Bliska, J.B., and Black, D.S., 1995, Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase, Infect. Immun. 63: 681–685.

    PubMed  CAS  Google Scholar 

  • Bliska, J.B., and Falkow, S., 1992, Bacterial resistance to complement killing mediated by the Ail protein of Yersinia enterocolitica, Proc. Natl. Acad. Sci. USA 89: 3561–3565.

    PubMed  CAS  Google Scholar 

  • Bliska, J.B., Guan, K.L., Dixon, J.E., and Falkow, S., 1991, A mechanism of bacterial pathogenesis: Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant, Proc. Natl. Acad. Sci. USA 88: 1187–1191.

    PubMed  CAS  Google Scholar 

  • Bliska, J.B., Clemens, J.C., Dixon, J.E., and Falkow, S., 1992, The Yersinia tyrosine phosphatase: specificity of a bacterial virulence determinant for phosphoproteins in the J774A.1 macrophage. J. Exp. Med. 176: 1625–1630.

    PubMed  CAS  Google Scholar 

  • Bliska, J.B., Copass, M.C., and Falkow, S., 1993, The Yersinia pseudotuberculosis adhesin YadA mediates intimate bacterial attachment to and entry into HEp-2 cells, Infect. Immun. 61: 3914–3921.

    PubMed  CAS  Google Scholar 

  • Boland, A., and Cornelis, G.R., 1998, Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection, Infect. Immun. 66: 1878 1884.

    Google Scholar 

  • Boland, A., Sory, M.-P., Iriarte, M., Kerbourch, C., Wattiau, P., and Cornelis, G.R., 1996, Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5–1.8 macrophages by the YopB, D, N delivery apparatus, EMBO J. 15: 5191–5201.

    PubMed  CAS  Google Scholar 

  • Bölin, I., and Wolf-Watz, H., 1988, The plasmid encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription, Mol. MicrobioL 2: 237–245.

    PubMed  Google Scholar 

  • Bölin, I., Norlander, L., and Wolf-Watz, H., 1982, Temperature-inducible outer membrane protein of Yersinia pseudotuberculosis and Yersinia enterocolitica is associated with the virulence plasmid, Infect. Immun. 37: 506–512.

    PubMed  Google Scholar 

  • Boyd, A.P., Sory, M.-P., Iriarte, M., and Cornelis, G.R., 1998, Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus, Mol. MicrobioL 27: 425–436.

    PubMed  CAS  Google Scholar 

  • Caron, E., Gross, A., Liautard, J: P., and Dornand, J., 1996, Brucella species release a specific, protease-sensitive, inhibitor of TNF-a expression, active on human macrophage-like cells, J. ImmunoL 156: 2885–2893.

    Google Scholar 

  • Cavanaugh, D.C., and Randall, R., 1959, The role of multiplication of Pasteurella pestis in mononuclear phagocytes in the pathogenesis of flea-borne plague. J. Immunol. 83: 348–363.

    PubMed  CAS  Google Scholar 

  • Charnetzky, W.T., and Shuford, W.W., 1985, Survival and growth of Yersinia pestis within macrophages and an effect of the loss of the 47-megadalton plasmid on growth in macrophages, Infect. Immun. 47: 234–241.

    PubMed  CAS  Google Scholar 

  • Cheng, L.W., Anderson, D.M., and Schneewind, 0., 1997, Two independent type III secretion mechanisms for YopE in Yersinia enterocolitica, Mol. Microbiol. 24: 757–765.

    PubMed  CAS  Google Scholar 

  • China, B., Michiels, T., and Cornelis, G.R., 1990, The pYV plasmid of Yersinia encodes a lipoprotein, YIpA, related to TraT, MoL Microbiol. 4: 1585–1593.

    PubMed  CAS  Google Scholar 

  • China, B., Sory, M.-P., N’Guyen, B.T., de Bruyere, M., and Comelis, G.R., 1993, Role of the YadA protein in prevention of opsonization of Yersinia enterocolitica by C3b molecules, Infect. Immun. 61: 3129–3136.

    PubMed  CAS  Google Scholar 

  • China, B., N’Guyen, B.T., de Bruyere, M., and Cornelis, G.R., 1994, Role of YadA in resistance of Yersinia enterocolitica to phagocytosis by human polymorphonuclear leukocytes, Infect. Immun. 62: 1275–1281.

    PubMed  CAS  Google Scholar 

  • Clark, M.A., Hirst, B.H., and Jepson, M.A., 1998, M-cell surface 01 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer’s patch M cells, Infect. Immun. 66: 1237–1243.

    PubMed  CAS  Google Scholar 

  • Cole, S.P., Guiney, D.G., and Corbeil, L.B., 1993, Molecular analysis of a gene encoding a serumresistance-associated 76kDa surface antigen of Haemophilus somnus. J. Gen. Microbiol. 139: 2135–2143.

    CAS  Google Scholar 

  • Collazo, C.M., and Galan, J.E., 1997, The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell, Mol. Microbiol. 24: 747–756.

    PubMed  CAS  Google Scholar 

  • Cornelis, G.R., Slithers, C., Delor, I., Geib, D., Kaniga, K., Lambert de Rouvroit, C.L., Sory, M.-P., Vanooteghem, J.-C., and Michiels, T., 1991, ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functions, Mol. Microbiol. 5: 1023–1034.

    Google Scholar 

  • Cornelis, G.R., Iriarte, M., and Sory, M.-P, 1995, Environmental control of virulence functions and signal transduction in Yersinia enterocolitica, in: Signal transduction and bacterial virulence ( R. Rappuoli, V. Scartato, and B. Arico, eds.), R.G. Landes company, Austin. pp. 95–110.

    Google Scholar 

  • Cornelis, G.R., Boland, A., Boyd, A.P., Geuijen, C., Iriarte, M., Neyt, C., Sory, M.-P., and Stainier, I., 1998, The virulence plasmid of Yersinia, an antihost genome, Micro. Mol. BioL Rev.,in press.

    Google Scholar 

  • Cover, T.L., and Aber, R.C., 1989, Yersinia enterocolitica, N. Engl. J. Med. 321: 16–24.

    CAS  Google Scholar 

  • De Marco, L., Mazzucato, M., Masotti, A., and Ruggeri, Z.M., 1994, Localization and charac-terization of an a-thrombin-binding site on platelet glycoprotein lba, J. Biol. Chem. 269: 6478–6484.

    PubMed  Google Scholar 

  • Deibel, C., Krämer, S., Chakraborty, T., and Ebel, E, 1998, EspE, a novel secreted protein of attaching and effacing bacteria, is directly translocated into infected host cells, where it appears as a tyrosine-phosphorylated 90kDa protein, Mol. Microbiol. 28: 463–474.

    PubMed  CAS  Google Scholar 

  • Delor, I., and Cornelis, G.R., 1992, Role of Yersinia enterocolitica Yst toxin in experimental infection of young rabbits, Infect. Immun. 60: 4269–4277.

    PubMed  CAS  Google Scholar 

  • Demuth, A., Goebel, W., Beuscher, H.U., and Kuhn, M., 1996, Differential regulation of cytokine and cytokine receptor mRNA expression upon infection of bone marrow-derived macrophages with Listeria monocytogenes, Infect. Immun. 64: 3475–3483.

    PubMed  CAS  Google Scholar 

  • Dunlevy, J.R., and Couchman, J.R., 1993, Controlled induction of focal adhesion disassembly and migration in primary fibroblasts, J. Cell Sci. 105: 489–500.

    PubMed  CAS  Google Scholar 

  • Emödy, L., Heesemann, J., Wolf-Watz, H., Skurnik, M., Kapperud, G., O’Toole, P., and Wadstrom, T., 1989, Binding to collagen by Yersinia enterocolitica and Yersinia pseudotuberculosis: evidence for yopA-mediated and chromosomally encoded mechanisms, J. Bacteriol. 171: 6674–6679.

    PubMed  Google Scholar 

  • Fällman, M., Andersson, K., Häkansson, S., Magnusson, K.E., Stendahl, O., and Wolf-Watz, H., 1995, Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells, Infect. Immun. 63: 3117–3124.

    Google Scholar 

  • Fällman, M., Persson, C., and Wolf-Watz, H., 1997, Yersinia proteins that target host cell signaling pathways, J. Clin. Invest. 99: 1153–1157.

    PubMed  Google Scholar 

  • Fields, K.A., Plano, G.V., and Straley, S.C., 1994, A low-Ca’ response (LCR) secretion (ysc) locus lies within the lcrB region of the LCR plasmid in Yersinia pestis, J. Bacteriol. 176: 569–579.

    PubMed  CAS  Google Scholar 

  • Forsberg, A., and Wolf-Watz, H., 1988, The virulence protein YopS of Yersinia pseudotuberculosis is regulated at transcriptional level by plasmid-plB1-encoded trans-acting elements controlled by temperature and calcium, Mol. Microbiol. 2: 121–133.

    PubMed  CAS  Google Scholar 

  • Forsberg, A., Viitanen, A.M., Skurnik, M., and Wolf-Watz, H., 1991, The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis, Mol. Microbiol. 5: 977–986.

    PubMed  CAS  Google Scholar 

  • Foster, R., Thorner, J., and Martin, G.S., 1989, Nucleotidylation, not phosphorylation, is the major source of the phosphotyrosine detected in enteric bacteria, J. Bacteriol. 171: 272–279.

    PubMed  CAS  Google Scholar 

  • Frithz-Lindsten, E., Du, Y., Rosqvist, R., and Forsberg, A., 1997, Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments, Mol. Microbiol. 25: 1125–1139.

    PubMed  CAS  Google Scholar 

  • Fu, Y., and Galan, J.E., 1998, The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton, Mol. Microbiol. 27: 359–368.

    PubMed  CAS  Google Scholar 

  • Galyov, E.E., Hdkansson, S., Forsberg, A., and Wolf-Watz, H., 1993, A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant, Nature 361: 730–732.

    PubMed  CAS  Google Scholar 

  • Galyov, E.E., HAkansson, S., and Wolf-Watz, H., 1994, Characterization of the operon encoding the YpkA Ser/Thr protein kinase and the YopJ protein of Yersinia pseudotuberculosis, J. Bacteriol. 176: 4543–4548.

    PubMed  CAS  Google Scholar 

  • Gemski, P., Lazere, J.R., and Casey, T., 1980a, Plasmid associated with pathogenicity and calcium dependency of Yersinia enterocolitica, Infect. Immun. 27: 682–685.

    PubMed  CAS  Google Scholar 

  • Gemski, P., Lazere, J.R., Casey, T., and Wohlhieter, J.A.,1980b, Presence of a virulence-associated plasmid in Yersinia pseudotuberculosis, Infect. Immun. 28: 1044–1047.

    Google Scholar 

  • Goguen, J.D., Walker, W.S., Hatch, T.P., and Yother, J., 1986, Plasmid-determined cytotoxicity in Yersinia pestis and Yersinia pseudotuberculosis, Infect. Immun. 51: 788–794.

    PubMed  CAS  Google Scholar 

  • Gralnick, H.R., Williams, S., McKeown, L.P., Hansmann, K., Fenton II, J.W., and Krutzsch, H., 1994, High-affinity a-thrombin binding to platelet glycoprotein Iba: identification of two binding domains, Proc. Natl. Acad. Sci. USA 91: 6334–6338.

    CAS  Google Scholar 

  • Green, S.P., Hartland, E.L., Robins Browne, R.M., and Phillips, W.A., 1995, Role of YopH in the suppression of tyrosine phosphorylation and respiratory burst activity in murine macrophages infected with Yersinia enterocolitica, J. Leukoc. Biol. 57: 972–977.

    PubMed  CAS  Google Scholar 

  • Grützkau, A., Hanski, C., Hahn, H., and Riecken, E.O., 1990, Involvement of M cells in the bacterial invasion of Peyer’s patches: a common mechanism shared by Yersinia enterocolitica and other enteroinvasive bacteria, GUT 31: 1011–1015.

    PubMed  Google Scholar 

  • Guan, K.L., and Dixon, J.E., 1990, Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia, Science 249: 553–556.

    PubMed  CAS  Google Scholar 

  • Guan, K.L., and Dixon, J.E., 1991, Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate, J. Biol. Chem. 266: 17026–17030.

    PubMed  CAS  Google Scholar 

  • Haimovich, B., Regan, C., DiFazio, L., Ginalis, E., Ji, P., Purohit, U., Rowley, R.B., Bolen, J., and Greco, R., 1996, The FcyRII receptor triggers pp125F^K phosphorylation in platelets, J. Biol. Chem. 271: 16332–16337.

    PubMed  CAS  Google Scholar 

  • Hâkansson, S., Bergman, T., Vanooteghem, J.-C., Cornelis, G., and Wolf-Watz, H., 1993, YopB and YopD constitute a novel class of Yersinia Yop proteins, Infect. Immun. 61: 71–80.

    PubMed  Google Scholar 

  • Hâkansson, S., Galyov, E.E., Rosqvist, R., and Wolf-Watz, H., 1996a, The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane, Mol. Microbiol. 20: 593–603.

    PubMed  Google Scholar 

  • Hâkansson, S., Schesser, K., Persson, C., Galyov, E.E., Rosqvist, R., Homble, E, and Wolf-Watz, H., 1996b, The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact dependent membrane disrupting activity, EMBO J. 15: 5812–5823.

    PubMed  Google Scholar 

  • Han, Y.W., and Miller, V.L., 1997, Reevaluation of the virulence phenotype of the inv yadA double mutants of Yersinia pseudotuberculosis, Infect. Immun. 65: 327–330.

    PubMed  CAS  Google Scholar 

  • Hanski, C., Kutschka, U., Schmoranzer, H.P., Naumann, M., Stallmach, A., Hahn, H., Menge, H., and Riecken, E.O., 1989, Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype 0:8 with intestinal mucosa during experimental enteritis, Infect. Immun. 57: 673–678.

    Google Scholar 

  • Hartland, E.L., Green, S.P., Phillips, W.A., and Robins Browne, R.M., 1994, Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica, Infect. Immun. 62: 4445–4453.

    PubMed  CAS  Google Scholar 

  • Heesemann, J., and Grater, L., 1987, Genetic evidence that the outer membrane protein Yopl of Yersinia enterocolitica mediates adherence and phagocytosis resistance to human epithelial cells, FEMS Microbiol. Letts. 40: 37–41.

    CAS  Google Scholar 

  • Holmström, A., Pettersson, J., Rosqvist, R., Hâkansson, S., Tafazoli, E, Fällman, M., Magnusson, K.E., Wolf-Watz, H., and Forsberg, A., 1997, YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane, Mol. Microbiol. 24: 73–91.

    PubMed  Google Scholar 

  • Iriarte, M., and Cornelis, G.R., 1995, MyfF, an element of the network regulating the synthesis of fibrillae in Yersinia enterocolitica, J. Bacteriol. 177: 738–744.

    PubMed  CAS  Google Scholar 

  • Iriarte, M., and Cornelis, G.R., 1998, YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Mol. Microbiol. in press.

    Google Scholar 

  • Iriarte, M., Vanooteghem, J.-C., Delor, I., Diaz, R., Knutton, S., and Cornelis, G.R., 1993, The Myf fibrillae of Yersinia enterocolitica, Mol. Microbiol. 9: 507–520.

    PubMed  CAS  Google Scholar 

  • Iriarte, M., Sory, M.-P, Boland, A., Boyd, A.P., Mills, S.D., Lambermont, I., and Cornelis, G.R., 1998, TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors, EMBO J. 17: 1907–1918.

    PubMed  CAS  Google Scholar 

  • Isberg, R.R., and Falkow, S., 1985, A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. Nature 317: 262–264.

    PubMed  CAS  Google Scholar 

  • Isberg, R.R., and Leong, J.M., 1990, Multiple ß, chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells, Cell 60: 861–871.

    PubMed  CAS  Google Scholar 

  • Isberg, R.R., and Tran Van Nhieu, G., 1995, The mechanism of phagocytic uptake promoted by invasin-integrin interaction, Trends Cell Biol. 5: 120–124.

    PubMed  CAS  Google Scholar 

  • Isberg, R.R., Voorhis, D.L., and Falkow, S., 1987, Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells, Cell 50: 769–778.

    PubMed  CAS  Google Scholar 

  • Isberg, R.R., Swain, A., and Falkow, S., 1988, Analysis of expression and thermoregulation of the Yersinia pseudotuberculosis inv gene with hybrid proteins, Infect. Immun. 56: 2133–2138.

    PubMed  CAS  Google Scholar 

  • Kapperud, G., Namork, E., and Skarpeid, H.J., 1985, Temperature-inducible surface fibrillae associated with the virulence plasmid of Yersinia entercolitica and Yersinia pseudotuberculosis, Infect. Immun. 47: 561–566.

    PubMed  CAS  Google Scholar 

  • Kobe, B., and Deisenhofer, J., 1994, The leucine-rich repeat: a versatile binding motif, Trends Biochem. Sci. 19: 415–420.

    PubMed  CAS  Google Scholar 

  • Koster, M., Bitter, W., de Cock, H., Allaoui, A., Cornelis, G.R., and Tommassen, J., 1997, The outer membrane component, YscC, of the Yop secretion machinery of Yersinia enterocolitica forms a ring-shaped multimeric complex, Mol. Microbiol. 26: 789–798.

    PubMed  CAS  Google Scholar 

  • Lachica, R.V., Zink, D.L., and Ferris, W.R., 1984, Association of fibril structure formation with cell surface properties of Yersinia enterocolitica, Infect. Immun. 46: 272–275.

    PubMed  CAS  Google Scholar 

  • Lambert de Rouvroit, C.L., Sluiters, C., and Cornelis, G.R., 1992, Role of the transcriptional activator, VirF, and temperature in the expression of the pYV plasmid genes of Yersinia enterocolitica, Mol. Microbiol. 6: 395–409.

    Google Scholar 

  • Lee, C., 1997, Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells? Trends Microbiol. 5: 148–155.

    PubMed  CAS  Google Scholar 

  • Lee, V.T., Anderson, D.M., and Schneewind, 0., 1998, Targeting of Yersinia Yop proteins into the cytosol of HeLa cells: one-step translocation of YopE across bacterial and eukaryotic membranes is dependent on SycE chaperone, Mol. Microbiol. 28: 593–601.

    PubMed  CAS  Google Scholar 

  • Leong, J.M., Fournier, R.S., and Isberg, R.R., 1990, Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein, EMBO J. 9: 1979–1989.

    PubMed  CAS  Google Scholar 

  • Leong, J.M., Morrissey, P.E., and Isberg, R.R., 1993, A 76-amino acid disulfide loop in the Yersinia pseudotuberculosis invasin protein is required for integrin receptor recognition, J. Biol. Chem. 268: 20524–20532.

    PubMed  CAS  Google Scholar 

  • Leong, J.M., Morrissey, P.E.; Marra, A., and Isberg, R.R., 1995, An aspartate residue of the Yersinia pseudotuberculosis invasin protein that is critical for integrin binding, EMBO J. 14: 422–431.

    PubMed  CAS  Google Scholar 

  • Leung, K.Y., and Straley, S.C., 1989, The yopM gene of Yersinia pestis encodes a released protein having homology with the human platelet surface protein GPIba, J. Bacteriol. 171: 4623–4632.

    PubMed  CAS  Google Scholar 

  • Leung, K.Y., Reisner, B.S., and Straley, S.C., 1990, YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice, Infect. Immun. 58: 3262–3271.

    PubMed  CAS  Google Scholar 

  • Lian, C.J., and Pai, C.H., 1985, Inhibition of human neutrophil chemiluminescence by plasmid-mediated outer membrane proteins of Yersinia enterocolitica, Infect. Immun. 49: 145–151.

    PubMed  CAS  Google Scholar 

  • Lian, C.J., Hwang, W.S., and Pai, C.H., 1987, Plasmid-mediated resistance to phagocytosis in Yersinia enterocolitica, Infect. Immun. 55: 1176–1183.

    PubMed  CAS  Google Scholar 

  • Lindler, L.E., Klempner, M.S., and Straley, S.C., 1990, Yersinia pestis pH 6 antigen: genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague, Infect. Immun. 58: 2569–2577.

    CAS  Google Scholar 

  • Mantle,M., Basaraba, L., Peacock, S.C., and Gall, D.G., 1989, Binding of Yersinia enterocolitica to rabbit intestinal brush border membranes, mucus, and mucin, Infect. Immun. 57:3292–3299.

    Google Scholar 

  • Marra, A., and Isberg, R.R., 1997, Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer’s patch intestinal epithelium, Infect. Immun. 65: 3412–3421.

    PubMed  CAS  Google Scholar 

  • Michiels, T., and Cornelis, G., 1988, Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703, Microb. Pathog. 5: 449–459.

    PubMed  CAS  Google Scholar 

  • Michiels, T., and Cornelis, G.R., 1991, Secretion of hybrid proteins by the Yersinia Yop export system, J. Bacteriol. 173: 1677–1685.

    PubMed  CAS  Google Scholar 

  • Michiels, T., Wattiau, P., Brasseur, R., Ruysschaert, J.M., and Cornelis, G., 1990, Secretion of Yop proteins by Yersiniae, Infect. Immun. 58: 2840–2849.

    PubMed  CAS  Google Scholar 

  • Michiels, T., Vanooteghem, J.-C., Lambert de Rouvroit, C.L., China, B., Gustin, A., Boudry, P., and Cornelis, G.R., 1991, Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica, J. Bacteriol. 173: 4994–5009.

    PubMed  CAS  Google Scholar 

  • Miller, V.L., and Falkow, S., 1988, Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells, Infect. Immun. 56: 1242–1248.

    PubMed  CAS  Google Scholar 

  • Mills, S.D., Boland, A., Sory, M.-P., Van der Smissen, P., Kerbourch, C., Finlay, B.B., and Cornelis, G.R., 1997, Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein, Proc. Natl. Acad. Sci. USA 94: 12638–12643.

    CAS  Google Scholar 

  • Mittler, R., and Lam, E., 1996, Sacrifice in the face of foes: pathogen-induced programmed cell death in plants, Trends. MicrobioL 4: 10–15.

    PubMed  CAS  Google Scholar 

  • Monack, D.M., Mecsas, J., Ghori, N., and Falkow, S., 1997, Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death, Proc. Natl. Acad. Sci. USA 94: 10385–10390.

    PubMed  CAS  Google Scholar 

  • Nakajima, R., and Brubaker, R.R., 1993, Association between virulence of Yersinia pestis and suppression of gamma interferon and tumor necrosis factor alpha, Infect. Immun. 61: 23–31.

    PubMed  CAS  Google Scholar 

  • Nakajima, R., Motin, V.L., and Brubaker, R.R., 1995, Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization, Infect. Immun. 63: 3021–3029.

    PubMed  CAS  Google Scholar 

  • Nilles, M.L., Williams, A.W., Skrzypek, E., and Straley, S.C., 1997, Yersinia pestis LcrV forms a stable complex with LcrG and may have a secretion-related regulatory role in the lowCa2 response, J. Bacteriol. 179: 1307–1316.

    CAS  Google Scholar 

  • Palmer, L.E., Hobbie, S., Galan, J.E., and Bliska, J.B., 1998, YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNFtx production and downregulation of the MAP kinases p38 and JNK, Mol. MicrobioL 27: 953–965.

    PubMed  CAS  Google Scholar 

  • Pepe, J.C., and Miller, V.L., 1993, Yersinia enterocolitica invasin: a primary role in the initiation of infection, Proc. Natl. Acad. Sci. USA 90: 6473–6477.

    CAS  Google Scholar 

  • Pepe, J.C., Badger, J.L., and Miller, V.L., 1994, Growth phase and low pH affect the thermal regulation of the Yersinia enterocolitica inv gene, Mol. Microbiol. 11: 123–135.

    PubMed  CAS  Google Scholar 

  • Pepe, J.C., Wachtel, M.R., Wagar, E., and Miller, V.L., 1995, Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB/c mouse model of infection, Infect. Immun. 63: 4837–4848.

    PubMed  CAS  Google Scholar 

  • Perona, R., Montaner, S., Saniger, L., Sanchez Perez, I., Bravo, R., and Lacal, J.C., 1997, Activation of the nuclear factor-kB by Rho, CDC42, and Rac-1 proteins, Genes. Dev. 11: 463–475.

    PubMed  CAS  Google Scholar 

  • Perry, R.D., and Brubaker, R.R., 1983, Vwa+ phenotype of Yersinia enterocolitica, Infect. Immun. 40: 166–171.

    PubMed  CAS  Google Scholar 

  • Persson, C., Nordfelth, R., Holmström, A., Häkansson, S., Rosqvist, R., and Wolf-Watz, H., 1995, Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell, Mol. Microbiol. 18: 135–150.

    PubMed  CAS  Google Scholar 

  • Persson, C., Carballeira, N., Wolf-Watz, H., and Fällman, M., 1997, The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130ce5 and FAK, and the associated accumulation of these proteins in peripheral focal adhesions, EMBO J. 16: 2307–2318.

    PubMed  CAS  Google Scholar 

  • Petruzzelli, L., Takami, M., and Herrera, R., 1996, Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130`°s and its association with c-CrkII, J. Biol. Chem. 271: 7796–7801.

    PubMed  CAS  Google Scholar 

  • Pettersson, J., Nordfelth, R., Dubinina, E., Bergman, T., Gustafsson, M., Magnusson, K.E., and Wolf-Watz, H., 1996, Modulation of virulence factor expression by pathogen target cell contact, Science 273: 1231–1233.

    PubMed  CAS  Google Scholar 

  • Plano, G.V., and Straley, S.C., 1993, Multiple effects of lcrD mutations in Yersinia pestis, J. Bacteriol. 175: 3536–3545.

    PubMed  CAS  Google Scholar 

  • Plano, G.V., and Straley, S.C., 1995, Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis, J. Bacteriol. 177: 3843–3854.

    PubMed  CAS  Google Scholar 

  • Plano, G.V., Barve, S.S., and Straley, S.C., 1991, LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response, J. Bacteriol. 173: 7293–7303.

    PubMed  CAS  Google Scholar 

  • Portnoy, D.A., and Falkow, S., 1981, Virulence-associated plasmids from Yersinia enterocolitica and Yersinia pestis, J. Bacteriol. 148: 877–883.

    PubMed  CAS  Google Scholar 

  • Reisner, B.S., and Straley, S.C., 1992, Yersinia pestis YopM: thrombin binding and overexpression, Infect. Immun. 60: 5242–5252.

    CAS  Google Scholar 

  • Roggenkamp, A., Neuberger, H.R., Flugel, A., Schmoll, T., and Heesemann, J., 1995, Substitution of two histidine residues in YadA protein of Yersinia enterocolitica abrogates collagen binding, cell adherence and mouse virulence, Mol. Microbiol. 16: 1207–1219.

    PubMed  CAS  Google Scholar 

  • Roggenkamp, A., Ruckdeschel, K., Leitritz, L., Schmitt, R., and Heesemann, J., 1996, Deletion of amino acids 29 to 81 in adhesion protein YadA of Yersinia enterocolitica serotype 0:8 results in selective abrogation of adherence to neutrophils, Infect. Immun. 64: 2506–2514.

    PubMed  CAS  Google Scholar 

  • Rosenshine, I., Duronio, V., and Finlay, B.B., 1992, Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells, Infect. Immun. 60: 2211–2217.

    PubMed  CAS  Google Scholar 

  • Rosqvist, R., Bölin, I., and Wolf-Watz, H., 1988, Inhibition of phagocytosis in Yersinia pseudo-tuberculosis: a virulence plasmid-encoded ability involving the Yop2b protein, Infect. Immun. 56: 2139–2143.

    PubMed  CAS  Google Scholar 

  • Rosqvist, R., Forsberg, A., Rimpilainen, M., Bergman, T., and Wolf-Watz, H., 1990, The cytotoxic protein YopE of Yersinia obstructs the primary host defence, Mol. Microbiol. 4: 657–667.

    PubMed  CAS  Google Scholar 

  • Rosqvist, R., Forsberg, A., and Wolf-Watz, H., 1991, Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption, Infect. Immun. 59: 4562–4569.

    PubMed  CAS  Google Scholar 

  • Rosqvist, R., Magnusson, K.E., and Wolf-Watz, H., 1994, Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells, EMBO J. 13: 964–972.

    PubMed  CAS  Google Scholar 

  • Ruckdeschel, K., Roggenkamp, A., Schubert, S., and Heesemann, J., 1996, Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils, Infect. Immun. 64: 724–733.

    PubMed  CAS  Google Scholar 

  • Ruckdeschel, K., Machold, J., Roggenkamp, A., Schubert, S., Pierre, J., Zumbihl, R., Liautard, J.-P., Heesemann, J., and Rouot, B., 1997a, Yersinia enterocolitica promotes deactivation of macrophage mitogen-activated protein kinases extracellular signal-regulated kinase-1/2, p38, and c-Jun NH2-terminal kinase, J. Biol. Chem. 272: 15920–15927.

    CAS  Google Scholar 

  • Ruckdeschel, K., Roggenkamp, A., Lafont, V., Mangeat, P., Heesemann, J., and Rouot, B., 1997b, Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis, Infect. Immun. 65: 4813–4821.

    PubMed  CAS  Google Scholar 

  • Ruckdeschel, K., Harb, S., Roggenkamp, A., Hornef, M., Zumbihl, R., Köhler, S., Heesemann, J., and Rouot, B., 1998, Yersinia enterocolitica impairs activation of transcription factor NF-KB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor a production, J. Exp. Med. 187: 1069–1079.

    CAS  Google Scholar 

  • Salmond, G.P., and Reeves, P.J., 1993, Membrane traffic ‘wardens and protein secretion in gram-negative bacteria, Trends Biochem. Sci. 18: 7–12.

    Google Scholar 

  • Saltman, L.H., Lu, Y., Zaharias, E.M., and Isberg, R.R., 1996, A region of the Yersinia pseudo-tuberculosis invasin protein that contributes to high affinity binding to integrin receptors, J. Biol. Chem. 271: 23438–23444.

    PubMed  CAS  Google Scholar 

  • Sarker, M.R., Neyt, C., Stainier, I., and Cornelis, G.R., 1998a, The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD, J. Bacteriol. 180: 1207–1214.

    PubMed  CAS  Google Scholar 

  • Sarker, M.R., Sory, M.-P., Boyd, A.P., Iriarte, M., and Cornelis, G.R., 1998b, LcrG is required for efficient internalization of Yersinia Yop effector proteins into eukaryotic cells, Infect. Immun. 66: 2976–2979.

    PubMed  CAS  Google Scholar 

  • Schesser, K., Frithz-Lindsten, E., and Wolf-Watz, H., 1996, Delineation and mutational analysis of the Yersinia pseudotuberculosis YopE domains which mediate translocation across bacterial and eukaryotic cellular membranes, J. Bacteriol. 178: 7227–7233.

    PubMed  CAS  Google Scholar 

  • Schesser, K., Spiik, A.-K., Dukuzumuremyi, J.-M., Neurath, M.F., Pettersson, S., and Wolf-Watz, H., 1998, The yopJ locus is required for Yersinia-mediated inhibition of NF-KB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity, Mol. Microbiol. 28: 1067–1079.

    PubMed  CAS  Google Scholar 

  • Schulze-Koops, H., Burkhardt, H., Heesemann, J., von der Mark, K., and Emmrich, F, 1992, Plasmid-encoded outer membrane protein YadA mediates specific binding of enteropathogenic Yersiniae to various types of collagen, Infect. Immun. 60: 2153–2159.

    PubMed  CAS  Google Scholar 

  • Schulze-Koops, H., Burkhardt, H., Heesemann, J., Kirsch, T., Swoboda, B., Bull, C., Goodman, S., and Emmrich, F, 1993, Outer membrane protein YadA of enteropathogenic Yersiniae mediates specific binding to cellular but not plasma fibronectin, Infect. Immun. 61: 2513–2519.

    PubMed  CAS  Google Scholar 

  • Shi, L., Mai, S., Israels, S., Browne, K., Trapani, J.A., and Greenberg, A.H., 1997, Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization, J. Exp. Med. 185: 855–866.

    PubMed  CAS  Google Scholar 

  • Siebers, A., and Finlay, B.B., 1996, M cells and the pathogenesis of mucosal and systemic infections, Trends. Microbiol. 4: 22–29.

    PubMed  CAS  Google Scholar 

  • Simonet, M., Richard, S., and Berche, P., 1990, Electron microscopic evidence for in vivo extra-cellular localization of Yersinia pseudotuberculosis harboring the pYV plasmid, Infect. Immun. 58: 841–845.

    PubMed  CAS  Google Scholar 

  • Simonet, M., Riot, B., Fortineau, N., and Berche, P., 1996, Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene, Infect. Immun. 64: 375–379.

    PubMed  CAS  Google Scholar 

  • Skrzypek, E., and Straley, S.C., 1993, LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis, J. Bacteriol. 175: 3520–3528.

    CAS  Google Scholar 

  • Skurnik, M., and Wolf-Watz, H., 1989, Analysis of the yopA gene encoding the Yopl virulence determinants of Yersinia spp, Mol. Microbiol. 3: 517–529.

    CAS  Google Scholar 

  • Skurnik, M., Bölin, I., Heikkinen, H., Piha, S., and Wolf-Watz, H., 1984, Virulence plasmid-associated autoagglutination in Yersinia spp, J. Bacteriol. 158: 1033–1036.

    PubMed  CAS  Google Scholar 

  • Skurnik, M., el Tahir, Y., Saarinen, M., Jalkanen, S., and Toivanen, P., 1994, YadA mediates specific binding of enteropathogenic Yersinia enterocolitica to human intestinal submucosa. Infect. Immun. 62: 1252–1261.

    PubMed  CAS  Google Scholar 

  • Smith, G.L., 1994, Virus strategies for evasion of the host response to infection, Trends Microbiol. 2: 81–88.

    PubMed  CAS  Google Scholar 

  • Sory, M.-P., and Cornelis, G.R., 1994, Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells, Mol. Microbio!. 14: 583–594.

    CAS  Google Scholar 

  • Sory, M.-P, Boland, A., Lambermont, I., and Cornelis, G.R., 1995, Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach, Proc. Natl. Acad. Sci. USA 92: 11998–12002.

    PubMed  CAS  Google Scholar 

  • Stainier, I., Iriarte, M., and Cornelis, G.R., 1997, YscMl and YscM2, two Yersinia enterocolit- ica proteins causing down regulation of yop transcription, Mol. Microbiol. 26: 833–843.

    PubMed  CAS  Google Scholar 

  • Straley, S.C., and Bowmer, W.S.,1986, Virulence genes regulated at the transcriptional level by Cat+ in Yersinia pestis include structural genes for outer membrane proteins, Infect. Immun. 51: 445–454.

    Google Scholar 

  • Symons, M., 1996, Rho family GTPases: the cytoskeleton and beyond, Trends. Biochem. Sci. 21: 178–181.

    PubMed  CAS  Google Scholar 

  • Tamm, A., Tarkkanen, A.M., Korhonen, T.K., Kuusela, P., Toivanen, P., and Skurnik, M., 1993, Hydrophobic domains affect the collagen-binding specificity and surface polymerization as well as the virulence potential of the YadA protein of Yersinia enterocolitica, Mol. Microbiol. 10: 995–1011.

    PubMed  CAS  Google Scholar 

  • Tang, X., Frederick, R.D., Zhou, J., Halterman, D.A., Jia, Y., and Martin, G.B., 1996, Initiation of plant disease resistance by physical interaction of AvrPto and Pto kinase, Science 274: 2060–2063.

    PubMed  CAS  Google Scholar 

  • Tertti, R., Skurnik, M., Vartio, T., and Kuusela, P., 1992, Adhesion protein YadA of Yersinia species mediates binding of bacteria to fibronectin, Infect. Immun. 60: 3021–3024.

    PubMed  CAS  Google Scholar 

  • Van Antwerp, D.J., Martin, S.J., Verma, I.M., and Green, D.R., 1998, Inhibition of TNF-a induced apoptosis by NF-KB, Trends Cell Biol. 8: 107–111.

    PubMed  Google Scholar 

  • Van den Ackerveken, G., Marois, E., and Bonas, U., 1996, Recognition of the bacterial avirulence protein AvrBs3 occurs inside the host plant cell, Cell 87: 1307–1316.

    PubMed  Google Scholar 

  • Vassalli, P., 1992, The pathophysiology of tumor necrosis factors, Annu. Rev. Immunol. 10: 411–452.

    PubMed  CAS  Google Scholar 

  • Visser, L.G., Annema, A., and van Furth, R., 1995, Role of Yops in inhibition of phagocytosis and killing of opsonized Yersinia enterocolitica by human granulocytes, Infect. Immun. 63: 2570–2575.

    PubMed  CAS  Google Scholar 

  • Wachtel, M.R., and Miller, V.L., 1995, In vitro and in vivo characterization of an ail mutant of Yersinia enterocolitica, Infect. Immun. 63: 2541–2548.

    CAS  Google Scholar 

  • Wattiau, P., and Cornelis, G.R., 1993, SycE, a chaperone-like protein of Yersinia enterocolitica involved in the secretion of YopE, Mol. Microbial. 8: 123–131.

    CAS  Google Scholar 

  • Wattiau, P., Bernier, B., Deslee, P., Michiels, T., and Cornelis, G.R., 1994, Individual chaperones required for Yop secretion by Yersinia, Proc. Natl. Acad. Sci. USA 91: 10493–10497.

    PubMed  CAS  Google Scholar 

  • Woestyn, S., Allaoui, A., Wattiau, P., and Cornelis, G.R., 1994, YscN, the putative energizer of the Yersinia Yop secretion machinery, J. Bacteriol. 176: 1561–1569.

    PubMed  CAS  Google Scholar 

  • Woestyn, S., Sory, M.-P., Boland, A., Lequenne, O., and Cornelis, G.R., 1996, The cytosolic SycE and SycH chaperones of Yersinia protect the region of YopE and YopH involved in translocation across eukaryotic cell membranes, Mol. Microbiol. 20: 1261–1271.

    PubMed  CAS  Google Scholar 

  • Wolff, C., Nisan, I., Hanski, E., Frankel, G., and Rosenshine, I., 1998, Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli, Mol. Microbiol. 28: 143–155.

    PubMed  CAS  Google Scholar 

  • Yang, Y., and Isberg, R.R., 1997, Transcriptional regulation of the Yersinia pseudotuberculosis pH6 antigen adhesin by two envelope-associated components, Mol. Microbiol. 24: 499–510.

    PubMed  CAS  Google Scholar 

  • Yang, Y., Merriam, J.J., Mueller, J.P., and Isberg, R.R., 1996, The psa locus is responsible for thermoinducible binding of Yersinia pseudotuberculosis to cultured cells, Infect. Immun. 64: 2483–2489.

    PubMed  CAS  Google Scholar 

  • Young, V.B., Falkow, S., and Schoolnik, G.K., 1992, The invasin protein of Yersinia enterocolitica: internalization of invasin-bearing bacteria by eukaryotic cells is associated with reorganization of the cytoskeleton, J. Cell Biol. 116: 197–207.

    Google Scholar 

  • Young, V.B., Miller, V.L., Falkow, S., and Schoolnik, G.K., 1990, Sequence, localization and func- tion of the invasin protein of Yersinia enterocolitica, Mol. Microbiol. 4: 1119–1128.

    Google Scholar 

  • Zaleska, M., Lounatmaa, K., Nurminen, M., Wahlstrom, E., and Makela, P.H., 1985, A novel virulence-associated cell surface structure composed of 47 kDa protein subunits in Yersinia enterocolitica, EMBO J. 4: 1013–1018.

    PubMed  CAS  Google Scholar 

  • Zhang, Z.Y., Clemens, J.C., Schubert, H.L., Stuckey, J.A., Fischer, M.W.F., Hume, D.M., Saper, M.A., and Dixon, J.E., 1992, Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase, J. Biol. Chem. 267: 23759–23766.

    PubMed  CAS  Google Scholar 

  • Zychlinsky, A., and Sansonetti, P., 1997, Apoptosis in bacterial pathogenesis, J. Clin. Invest. 100: 493–496.

    PubMed  CAS  Google Scholar 

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    Anne Boland & Guy R. Cornelis

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Boland, A., Cornelis, G.R. (2000). Interaction of Yersinia with Host Cells. In: Oelschlaeger, T.A., Hacker, J. (eds) Bacterial Invasion into Eukaryotic Cells. Subcellular Biochemistry, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4580-1_14

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