Skip to main content

Replication and Analysis of DNA

  • Chapter
Bacterial and Bacteriophage Genetics
  • 357 Accesses

Abstract

The study of genetics is really the study of the properties, synthesis, and inheritance of nucleic acids. Most of the topics in this book revolve around deoxyribonucleic acid (DNA), although some of the viruses discussed in later chapters have ribonucleic acid (RNA) as their genetic material. This chapter presents basic information about DNA and the methods used to study it. The material is fundamental for all discussions that follow.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

General

  • Baker, TA., Bell, S.P. (1998). Polymerases and the replisome: Machines within machines. Cell 92: 295–305 .

    Article  PubMed  CAS  Google Scholar 

  • Bickle, TA., Krüger, D.H. (1993). Biology of DNA restriction. Microbiological Reviews 57: 434–450.

    PubMed  CAS  Google Scholar 

  • Casjens, S. (1998). The diverse and dynamic structure of bacterial genomes. Annual Review of Genetics 12: 339–377.

    Article  Google Scholar 

  • Drlica, K., Riley, M. (1990). A historical introduction to the bacterial chromosome. In: Drlica, K., Riley, M. (eds.), The Bacterial Chromosome. Washington, DC: American Society for Microbiology. (An excellent overview.)

    Google Scholar 

  • Drlica, K., Pruss, G.J., Burger, R.M., Franco, R.J., Hsieh, L.-S., Berger, B.A. (1990). Roles of DNA topoisomerases in bacterial chromosome structure and function. In: Drlica, K., Riley, M. (eds.), The Bacterial Chromosome. Washington, DC: American Society for Microbiology.

    Google Scholar 

  • Jumas-Bilak, E., Michaux-Charachon, S., Bourg, G., Ramuz, M., Allardet-Servent, A. (1998) Unconventional genomic organization in the alpha subgroup of the Proteobacteria. Journal of Bacteriology 180: 2749–2755.

    PubMed  CAS  Google Scholar 

  • Kornberg, A., Baker, T.A. (1992). DNA Replication, second edition. San Francisco: W.H. Freeman.

    Google Scholar 

  • Losick, R., Shapiro, L. (1998). Bringing the mountain to Mohammed. Science 282: 1430–1431. (A review of evidence for a DNA replication factory through which DNA moves.)

    Article  PubMed  CAS  Google Scholar 

  • Sueoka, N. (1998). Cell membrane and chromosome replication in B. subtilis. Progress in Nucleic Acid Research and Molecular Biology 59: 35–53.

    Article  CAS  Google Scholar 

Specialized

  • Choudhary, M., Mackenzie, C., Nereng, K., Sodergren, E., Weinstock, G.M., Kaplan, S. (1997). Low-resolution sequencing of Rhodobacter sphaeroides 2.4.1 T: Chromosome II is a true chromosome. Microbiology-UK 143: 3085–3099.

    Article  CAS  Google Scholar 

  • Kim, S., Dallmann, H.G., McHenry, C.S., Marians, K.J. (1996). Coupling of a replicative polymerase and helicase: a T-DnaB interaction mediates rapid replication fork movement. Cell 84: 643–650.

    Article  PubMed  CAS  Google Scholar 

  • Lemon, K.P. , Grossman, A.D. (1998). Localization of bacterial DNA polymerase: Evidence for a factory model of replication. Science 282: 1516–1519.

    Article  PubMed  CAS  Google Scholar 

  • Lin, D.C.H., Grossman, A.D. (1998). Identification and characterization of a bacterial chromosome partitioning site. Cell 92: 675–685.

    Article  PubMed  CAS  Google Scholar 

  • Lukomski, S., Wells, R.D. (1994). Left-handed Z-DNA and in vivo supercoil density in the Escherichia coli chromosome. Proceedings of tbe National Academy of Sciences of the USA 91: 9980–9984.

    Article  CAS  Google Scholar 

  • Poplawski, A., Bernander, R. (1997). Nucleoid structure and distribution in thermophilic Archaea. Journal of Bacteriology 179: 7625–7630.

    PubMed  CAS  Google Scholar 

  • Steiner, W., Liu, G., Donachie, W.D., Kuempel, P. (1999). The cytoplasmic domain of Ftsk protein is required for resolution of chromosome dimers, Molecular Microbiology 31: 579–583.

    Article  PubMed  CAS  Google Scholar 

  • Takayanagi, S., Morimura, S., Kusaoke, H., Yokoyama, Y., Kano, K., Shioda, M. (1992.) Chromosomal structure of the halophilic archaebacterium Halobacterium salinarium, Journal of Bacteriology 174: 7207–7216.

    PubMed  CAS  Google Scholar 

  • Teleman, A.A., Graumann, PL., Lin, D.C.H., Grossman, A.D., Losick, R. (1998). Chromosome arrangement within a bacterium. Current Biology 8: 1102–1109.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Science+Business Media New York

About this chapter

Cite this chapter

Birge, E.A. (2000). Replication and Analysis of DNA. In: Bacterial and Bacteriophage Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-3258-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-3258-0_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-3260-3

  • Online ISBN: 978-1-4757-3258-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics