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DNA Repair Pathways and Cancer Prevention

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Advances in Nutrition and Cancer 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 472))

Abstract

This article describes the five main classes of DNA repair processes that occur in humans with respect to their mechanism of action, major substrates, and role in protection against endogenous and environmental DNA damaging agents. The importance of all of these processes in protection from the initiation of neoplastic growth has been established either in studies of inheritable diseases affecting DNA repair or experiments with transgenic animals or both. The capacity of DNA repair pathways to deal with DNA damage is therefore a critical factor in the cellular response to environmental, and dietary carcinogens. DNA repair activity and factors affecting this activity either directly or indirectly must be taken into account in risk assessment.

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Authors and Affiliations

  1. Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine The Milton S. Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania, 17033, USA

    Anthony E. Pegg

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  1. Anthony E. Pegg
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Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, Second University of Naples, Naples, Italy

    Vincenzo Zappia  & Fulvio Della Ragione  & 

  2. Institute of Clinical Surgery, Second University of Naples, Naples, Italy

    Alfonso Barbarisi

  3. Institute of Food Science and Technology, National Research Council, Avellino, Italy

    Gian Luigi Russo

  4. National Cancer Institute, Fondazione “Giovanni Pascale”, Naples, Italy

    Rossano Dello Iacovo

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Pegg, A.E. (1999). DNA Repair Pathways and Cancer Prevention. In: Zappia, V., Della Ragione, F., Barbarisi, A., Russo, G.L., Iacovo, R.D. (eds) Advances in Nutrition and Cancer 2. Advances in Experimental Medicine and Biology, vol 472. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3230-6_22

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  • DOI: https://doi.org/10.1007/978-1-4757-3230-6_22

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