Abstract
Skin aging is accompanied by biochemical, morphological and Theological changes (Banga, 1966, 1972; Fleischmajer et al., 1973; Hall, 1976; Viidik, 1973, 1982). Many people desire to reduce these senile changes as there are an increase of collagen concentration (Gillman, 1970) with a concomitant decrease of total collagen due to skin thinning (Viidik, 1982), a decrease of soluble collagen (Harris and Sjoerdsma, 1966; Verzár, 1964) by higher crosslinking of collagen, leading to an increasing fibre stiffness (Bailey and Robins, 1973). Moreover, there is a loss of ground substance (proteoglycans (PG), mainly hyaluronate and dermatan sulphate, as first stated by Clausen (1962)), and therefore we observe a decreasing hydration of the matrix by dysregulation of homeostasis. The content of elastin increases (Pearce and Grimmer, 1972), and there are pronounced changes in the network of elastic fibres (Viidik, 1982). All these changes are manifested phenomenologically in the formation of more wrinkles, increasing dryness and, mechanically, in a loss of elasticity. Changes of the matrix result from genetically scheduled enzymatic mechanisms (Hayflick, 1982), but more often from stochastic processes with an endogenous or an exogenous origin.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bailey, A.J., and Robins, S.P., 1973, Development and Maturation of the Crosslinks of the Collagen Fibres of the Skin, in: “Front.Matrix Biol., Vol. 1”, L. Robert, P. Robert, ed., Karger, Basel.
Banga, I., 1966, “Structure and Function of Elastin and Collagen”, Akadémiai Kiadó, Budapest.
Banga, I., 1972, Methoden zur Untersuchung der Veränderungen der physikalischen Eigenschaften des Bindegewebes im Altersgang, Z. Alternsforsch., 25:247.
Blix, G., 1948, The determination of hexosamines, Acta chemscand., 2:476.
Clausen, B., 1962, Influence of age on connective tissue, Lab.Invest., 11:229.
Danielsen, L., 1979, “Morphological Changes in Pseudoxanthoma Elasticum and Senile Skin”, FADL Publication Co., Copenhagen.
Fleischmajer, R., Perlish, J.S., and Bashey, R.I., 1973, Aging of Human Dermis, in: “Front.Matrix Biol., Vol.1”, L. Robert, P. Robert, ed., Karger, Basel.
Gillman, T., 1970, “The Dermis”, Blackwell Scientific Publications, London.
Hall, D.A., 1976, “The Aging of Connective Tissue”, Acad.Press, New York.
Harris, E., and Sjoerdsma, A., 1966, Collagen content, solubility and cross-linking in human dermis, J.clin.Invest., 45:1020.
Hayflick, L., 1982, Ageing and Death of Vertebrate Cells, in: “Lectures on Gerontology, Vol.I/A”, Acad.Press, New York.
Heikkinen, E., 1968, Transformation of rat skin collagen, Acta physiol.scand., 74, suppl.317:1.
Heikkinen, E., 1973, Ageing of Interstitial Collagen, in: “Front.Matrix Biol., Vol.1”, L. Robert, P. Robert, ed., Karger, Basel.
Jarret, A., 1974, “The Physiology and Pathophysiology of Skin, Vol.3”, Acad. Press, London and New York.
Niedermüller, H., Skalicky, M., Hofecker, G., and Kment, A., 1977, Investigations on the kinetics of collagen-metabolism in young and old rats, Exp.Gerontol., 12:159.
Pav, E., Kment, A., Hofecker, G., Tielsch, W., and Niedermüller, H., 1975, Dehnungsmessungen an der Rattenaorta I, akt.gerontol., 5:453.
Pav, E., Hofecker, G., Kment, A., and Niedermüller, H., 1977, Dehnungsmessungen an der Rattenaorta II, akt.gerontol., 7:529.
Pav, E., Hofecker, G., Kment, A., Skalicky, M., and Niedermüller, H., Dehnungsmessungen an der Rattenaorta III, akt.gerontol., 8:261.
Pearce, R.H., and Grimmer, B.J., 1972, Age and the chemical constitution of normal human dermis, J.invest.Derm., 58:347.
Remington, J.W., 1955, Hysteresis loop behaviour of the aorta and other extensible tissues, Amer.J.Physiol., 180:83.
Robert, B., and Robert, L., 1973, Aging of Connective Tissues. General Considerations, in: “Front.Matrix Biol., Vol.1”, L. Robert, P. Robert, ed., Karger, Basel.
Selmanowitz, V.J., Rizer, R.L., Orentreich, L., 1977, Aging of the Skin and its Appendages, in: “Handbook of the Biology of Aging”, C.E. Finch, L. Hayflick, ed., Van Nostrand Reinhold, New York.
Shuster, S., and Bottoms, E., 1967, Effect of Ultra-violet Radiation on Skin Collagen of Intact Living Mice, Nature, 214:599.
Stegemann, H., 1958, Mikrobestimmung von Hydroxyprolin mit Chloramin-T und p-Dimethylaminobenzaldehyd, Z.Physiol.Chem., 311:41.
Verzar, F., 1964, Ageing of the collagen fibre, Int.Rev.Conn.Tissue Res., 2:243.
Viidikj, A., 1973, Rheology of Skin with Special Reference to Age-Related Parameters and their Possible Correlation to Structure, in: “Front.Matrix Biol., Vol.l”, L. Robert, P. Robert, ed., Karger, Basel.
Viidik, A., 1980, Mechanical Properties of Parallel-fibred Collagenous Tissues, in: “Biology of Collagen”, A. Viidik, J. Vuust, ed., Acad.Press, London and New York.
Viidik, A., 1982, Age-related Changes in Connective Tissues, in: “Lectures on Gerontology, Vol.1”, A. Viidik, ed., Acad.Press, London and New York.
Vogel, H.G., 1976, Altersabhängige Veränderungen der mechanischen und biochemischen Eigenschaften der Cutis bei Ratten, akt.gerontol., 6:477.
Vogel, H.G., 1978, Age Dependence of Mechanical Parameters in Rat Skin Following Repeated Strain, akt.gerontol., 8:601.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Niedermüller, H., Petersen, RD. (1988). The Influence of Age, Proteoglycans and UV-Irradiation on Biochemical and Rheological Parameters of Rat’s Skin. In: Zappia, V., Galletti, P., Porta, R., Wold, F. (eds) Advances in Post-Translational Modifications of Proteins and Aging. Advances in Experimental Medicine and Biology, vol 231. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9042-8_54
Download citation
DOI: https://doi.org/10.1007/978-1-4684-9042-8_54
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-9044-2
Online ISBN: 978-1-4684-9042-8
eBook Packages: Springer Book Archive