Abstract
Chymosin (EC 3.4.23.4) is an aspartyl proteinase synthesized in the chief and mucous neck cells of the gastric glands in the fourth stomach of newborn calves (Andren et al., 1982). Chymosin is also found in other mammalian species [for example, in newborn pig (Foltmann et al., 1977; Foltmann et al., 1981), cat (Jensen et al., 1982), seal (Shamsuzzaman & Haard, 1984) and lamb (Baudys et al, 1988; Pungerčar et al., 1990)].
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Andren, A., Björck, L. & Claesson, O., 1982, Immunohistochemical studies on the development of prochymosin-and pepsinogen-containing cells in bovine abomasal mucosa, J. Physiol., 327: 247–254.
Baudyš, M., Erdene, T. G., Kostka, V., Pavlik, M. & Foltmann, B., 1988, Comparison between prochymosin and pepsinogen from lamb and calf, Comp. Biochem. Physiol, 89B: 385–391.
Foltmann, B., Lonblad, P. & Axelsen, N. H., 1977, Demonstration of chymosin (EC 3.4.23.4) in the stomach of newborn pig, Biochem. J., 169: 425–427.
Foltmann, B., Pedersen, V. B., Jacobsen, H., Kauffman, D. & Wybrandt, G., 1977, The complete amino acid sequence of prochymosin, Proc. Natl. Acad. Sci. USA, 74: 2321–2324.
Foltmann, B., Jensen, A. L., Lonblad, P., Axelsen, E. & Axelsen, N. H., 1981, A developmental analysis of the production of chymosin and pepsin in pigs, Comp. Biochem. Physiol., 68B: 9–13.
Henschel, M. J., Newport, M. J. & Parmar, V., 1987, Gastric proteases in the human infant. Biol. Neonate, 52: 268–272.
Hidaka, M., Sasaki, K., Uozumi, T. & Beppu, T., 1986, Cloning and structural analysis of the calf prochymosin gene, Gene, 43: 197–203.
Jensen, T., Axelsen, N. H. & Foltmann, B., 1982, Isolation and partial characterization of prochymosin and chymosin from cat, Biochim. Biophys. Acta, 705: 249–256.
Kolmer, M., Örd, T., Alhonen, L., Hyttinen, J.-M., Saarma, M., Villems, R. & Jänne, J., 1990, Assignment of Human Prochymosin Pseudogene to Chromosome 1, Genomics, submitted.
Malpress, F. H., 1967, Rennin and the gastric secretion of normal infants, Nature, 215: 855–857.
Navia, M. A., Fitzgerald, P. M. D., McKeever, B. M., Leu, C.-T., Heimbach, J. C., Herbar, W. K., Sigal, I. S., Darke, P. L. & Springer, J. P., 1989, Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1, Nature, 337: 615–620.
Pedersen, V. B., Christensen, K, A. & Foltmann, B., 1979, Investigations on the activation of bovine prochymosin, Eur. J. Biochem., 94: 573–580.
Pearl, L. H. & Taylor, W. R., 1987, A structural model for the retroviral proteases, Nature, 329: 351–354.
Pungerčar, J., Strukelj, B., Gubensek, H., Turk, V. & Kregar, I., 1990, Complete primary structure of lamb preprochymosin deduced from cDNA, Nucl. Acids Res., 18: 4602.
Shamsuzzaman, K. & Haard, N. F., 1984, Purification and characterization of a chymosin-like protease from the gastric mucosa of harp seal (Pagophilus groenlandicus), Can. J. Biochem. Cell Biol., 62: 699–708.
Sogawa, K., Fujii-Kuriyama, Y., Mizukami, Y., Ichihara, Y. & Takahashi, K., 1983, Primary structure of human pepsinogen gene, J. Biol. Chem., 258: 5306–5311.
Warner, T. F., Donnelly, J., Reza-Hafez, G., Renwick, B., Engstrand, D. & Bareness, L., 1986, Immunochemical evidence for gastric proteases in adenocarcinoma of the stomach, Cancer, 58: 1328–1332.
Örd, T., Kolmer, M., Villems, R. & Saarma, M., 1990, Structure of the human genomic region homologous to the bovine prochymosin-encoding gene, Gene, 91: 241–246.
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© 1991 Plenum Press, New York
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Örd, T., Kolmer, M., Jänne, J., Villems, R., Saarma, M. (1991). Structure and Chromosomal Localization of the Human Prochymosin Pseudogene. In: Dunn, B.M. (eds) Structure and Function of the Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 306. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6012-4_15
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DOI: https://doi.org/10.1007/978-1-4684-6012-4_15
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