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Structural Studies of Pig Lens Aldose Reductase: Reversible Dimerization of the Enzyme

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Enzymology and Molecular Biology of Carbonyl Metabolism 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 284))

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Abstract

Drugs inhibiting Aldose Reductase (AR) may have a profound therapeutic impact for patients suffering for diabetes Mellitus. However, a prerequisite for such a long term treatment is the absence of side effects. For the drug design, the knowledge of the structure of AR will be a most useful contribution and will answer a number of puzzling facts such as the surprisingly large number of aldehydes which are substrates for AR. In this account, we present preliminary results of a structural study of pig lens Aldose Reductase.

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References

  1. Fenn, J.B., Mann, M., Meng, CK., Wong, S.F., and Whitehouse,C.M., Electrospray Ionization for Mass Spectrometry of Large Biomolecules, Science, 246: 64, (1989).

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Authors and Affiliations

  1. Biostructure, 8 rue Gustave Hirn, 67000, Strasbourg, France

    Jean-Michel Rondeau

  2. Laboratoire de Cristallographie Biologique, I.B.M.C., C.N.R.S., 15 rue Rene Descartes, 67084, Strasbourg, France

    Dino Moras, Frédérique Tête & Alberto Podjarny

  3. Laboratoire de Chimie Organique des Substances Naturelles, URA 31, Département de Chimie, Université Louis Pasteur, 1 rue Blaise Pascal, 67008, Strasbourg, France

    Alain Van Dorsselaer

  4. Laboratoire de Chimie Organique Biologique, URA 31, Département de Chimie, Université Louis Pasteur, 1 rue Blaise Pascal, 67008, Strasbourg, France

    Jean-Marc Reymann, Patrick Barth & Jean-François Biellmann

Authors
  1. Jean-Michel Rondeau
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  2. Dino Moras
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  3. Frédérique Tête
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  4. Alberto Podjarny
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  5. Alain Van Dorsselaer
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  6. Jean-Marc Reymann
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  7. Patrick Barth
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  8. Jean-François Biellmann
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Purdue University, West Lafayette, Indiana, 47907, USA

    Henry Weiner

  2. Chemisches Zentrallabor, Inselspital, Bern, CH 3010, Switzerland

    Bendicht Wermuth

  3. Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana, 46202, USA

    David W. Crabb

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© 1990 Plenum Press, New York

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Rondeau, JM. et al. (1990). Structural Studies of Pig Lens Aldose Reductase: Reversible Dimerization of the Enzyme. In: Weiner, H., Wermuth, B., Crabb, D.W. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology, vol 284. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5901-2_14

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  • DOI: https://doi.org/10.1007/978-1-4684-5901-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5903-6

  • Online ISBN: 978-1-4684-5901-2

  • eBook Packages: Springer Book Archive

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