Abstract
Many indole compounds, including dietary indoles such as indole-3-carbinol [I-3- C], have been shown to protect against chemical carcinogenesis (Wattenberg 1983) and chemically induced hepatotoxicity (Shertzer et al. 1987a, 1987b, 1988a). Such protection may be due to the ability of I-3-C to scavenge biologically reactive electrophiles (Shertzer et al. 1987b, 1988b) and free radicals (Shertzer et al. 1987a; Shertzer et al. 1988a). To develop better chemoprotective indoles with lower intrinsic toxicity, 28 structurally related indoles were investigated relative to antioxidant efficacies and physicochemical properties (Log P and electronic effects).
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© 1991 Plenum Press, New York
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Tabor, M.W., Coats, E., Sainsbury, M., Shertzer, H.G. (1991). Antioxidation Potential of Indole Compounds — Structure Activity Studies. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_116
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DOI: https://doi.org/10.1007/978-1-4684-5877-0_116
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