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Ornithine Decarboxylase Antizyme in Mammalian Tissues

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Progress in Polyamine Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

Abstract

Antizyme was first described by Canellakis and coworkers (1) as a protein inhibitor of ornithine decarboxylase which is induced in response to an elevated level of putrescine in cells in culture or in liver of rats treated with putrescine. It was characterized as protease-sensitive, nuclease- insensitive and heat-labile, while the inhibition is concentration-dependent, time-independent and non-competitive with respect to ornithine (1).

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References

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada

    Margaret E. Brosnan & Yu-Wan Hu

Authors
  1. Margaret E. Brosnan
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  2. Yu-Wan Hu
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Editor information

Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

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© 1988 Plenum Press, New York

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Brosnan, M.E., Hu, YW. (1988). Ornithine Decarboxylase Antizyme in Mammalian Tissues. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_4

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  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

  • eBook Packages: Springer Book Archive

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