Abstract
A satisfactory agent for boron neutron capture therapy (BNCT) must bind tumor cells in preference to normal cellular elements of the brain. However, it must also be delivered in sufficient concentration to the tumor cells by the bloodstream. The latter depends upon the degree of uptake or binding of the agent by blood cells or plasma proteins, the blood flow within the tumor, the permeability of the tumor vasculature to the particular boronated agent, and the distribution volumes of the agent within the tumor and adjacent brain tissue1,2.
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© 1989 Plenum Press, New York
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Tyson, G., Fenstermacher, J., Davis, R. (1989). Vascular Factors Affecting Drug Delivery to Brain Tumors. In: Fairchild, R.G., Bond, V.P., Woodhead, A.D., Vivirito, K. (eds) Clinical Aspects of Neutron Capture Therapy. Basic Life Sciences, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5622-6_16
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