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Haemopoietic Regulation and the Role of the Macrophage in Erythropoietic Gene Expression

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Molecular Biology of Hemopoiesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 34))

Abstract

The macrophage is considered as an “active” component of the haemopoietic cellular microenvironment with respect to erythropoietin (epo) production during embryonic, foetal and adult erythropoiesis. Emphasis is placed on steady-state rather than pathophysiological conditions. In addition, the signals capable of affecting the functional capacity of the macrophage with regard to colony stimulating factor and epo production are also taken into account. Evidence is given demonstrating that a subpopulation of resident macrophages in vitro and in the mouse bone marrow, under normal conditions, can express the epo gene. These results indicate that erythropoiesis can be regulated by short-range or cell-to-cell interactions within the bone marrow.

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Author information

Authors and Affiliations

  1. Department of Transfusion Medicine, University of Ulm, Ulm, Germany

    Ivan N. Rich

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  1. Ivan N. Rich
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Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, University of Mississippi, Jackson, Mississippi, USA

    Mehdi Tavassoli

  2. Veterans Administration Medical Center, University of Nevada, Reno, Nevada, USA

    Esmail D. Zanjani

  3. New York Medical College, Valhalla, New York, USA

    Joao L. Ascensao  & Nader G. Abraham  & 

  4. Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

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© 1988 Plenum Press, New York

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Rich, I.N. (1988). Haemopoietic Regulation and the Role of the Macrophage in Erythropoietic Gene Expression. In: Tavassoli, M., Zanjani, E.D., Ascensao, J.L., Abraham, N.G., Levine, A.S. (eds) Molecular Biology of Hemopoiesis. Advances in Experimental Medicine and Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5571-7_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5571-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5573-1

  • Online ISBN: 978-1-4684-5571-7

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