Skip to main content
SpringerLink
Log in

Gastrointestinal Allergy and Food Hypersensitivity

  • Chapter
Nutrition and Diet Therapy in Gastrointestinal Disease

Part of the book series: Topics in Gastroenterology ((TGEN))

  • 157 Accesses

Abstract

Allergy has been simply defined as altered reactivity, but to many it implies an adverse reaction that occurs due to the interaction of an antigen with antibody or lymphoid cells.l,la Although there is tremendous interest, the clinical significance of gastrointestinal allergy and food hypersensitivity is uncertain, as the science of the field is in its infancy. The allergists have been inundated by patients who claim all sorts of symptoms from food intake and the art of allergy has responded with intermittent success, but the science of proving food hypersensitivity has been limited. The only clinical situations that have been established as disease entities due to food hypersensitivity are cow's milk intolerance and gluten enteropathy. Although eosinophilic gastroenteritis is suspected of being related to food and hypersensitivity, the association has not been proven. There is no question humans must have numerous intolerances and hypersensitivities to foods, but much research has to evolve before the subject is understood in more detail. The following facts appear certain and may be of help in management of suspected gastrointestinal allergy or food hypersensitivity. It is important to make the distinction that gastrointestinal allergy refers to allergic responses that are manifest within the gastrointestinal tract, whereas food hypersensitivity may be a hypersensitivity state caused by the ingestion of food with symptoms occurring in the gastrointestinal tract, or at other target organs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Editorial: Food allergy. Lancet 1: 249, 1979.

    Google Scholar 

  2. la. Gleich GJ: IgE, allergy, and the gut. Dig Dis Sci 25: 321, 1980.

    Article  Google Scholar 

  3. Freir S: Paediatric gastrointestinal allergy.Clin Allergy 3: 597, 1973.

    Google Scholar 

  4. Ishizaka K, Ishizaka T: Identification of gamma E antibodies as a carrier of reaginic activity. J Immunol 99: 1187, 1967.

    CAS  Google Scholar 

  5. Ishizaka K, Ishizaka T, Hornbrook MM: Physiochemical properties of reaginic antibody. V. Correlation of reaginic activity with E-globulin antibody.J Immunol 97: 840, 1966.

    CAS  Google Scholar 

  6. Heiner DC, Rose B: Elevated levels of gamma E (IgE) in conditions other than classical allergy. J Allergy 45: 31, 1970.

    Google Scholar 

  7. Coombs RRA, Hunter A, Jones WE, et al: Detection of IgE (IgND) specific antibody (probably ragin) to castor bean allergen by the red-cell-linked antigen—antiglobulin reaction. Lancet i: 1115, 1968.

    Google Scholar 

  8. Kletter B Gery I, Freier S, et al: Immunoglobulin E antibodies to milk proteins.Clin Allergy 1:249, 1971.

    Google Scholar 

  9. Tada T, Ishizaka K: Distribution of IgE forming cells in lymphoid tissues of the human and monkey.Jlmmunol 104: 377, 1970.

    CAS  Google Scholar 

  10. Ferguson A: Models of intestinal hypersensitivity.Clin Gastroenterol 5: 271, 1976.

    CAS  Google Scholar 

  11. Editorial: Antigen absorption by the gut. Lancet 2: 715, 1978.

    Google Scholar 

  12. Walker WA, Isselbacher KJ: Uptake and transport of macromolecules by the intestine. Gastroenterology 67: 531, 1974.

    CAS  Google Scholar 

  13. Hemmings WA:Antigen Absorption by the Gut. Lancaster: MTP Press, 1978, pp 170, 181.

    Google Scholar 

  14. Owen RL, Jones AL: Epithelial cell specialization within human Peyer’s patches. An ultra-structural study of intestinal lymphoid follicles. Gastroenterology 66: 189, 1974.

    CAS  Google Scholar 

  15. Hemmings WA, Williams EW: Transport of large breakdown products of dietary protein through the gut wall. Gut 19: 715, 1978.

    Article  CAS  Google Scholar 

  16. Warshan AL, Walker WA, Isselbacher KJ: Protein uptake by the intestine: Evidence for absorption of intact macromolecules. Gastroenterology 66: 987, 1974.

    Google Scholar 

  17. Falchuk KR, Isselbacher KJ: Circulating antibodies to bovine albumin in ulcerative colitis and Crohn’s disease. Gastroenterology 70: 5, 1976.

    CAS  Google Scholar 

  18. May CD, Bock SA: Adverse reactions to food due to hypersensitivity, in Middleton E, Reed CE, Ellis CF (eds):Allergy, Principles and Practice. St Louis: CV Mosby, 1978, p 1159.

    Google Scholar 

  19. Goldstein GB, Heimer DC: Clinical and immunological perspectives in food sensitivity: A review.J Allergy 46: 270, 1970.

    CAS  Google Scholar 

  20. Bock SA, Buckley J, Holst A, et al: Proper use of skin tests with food extracts in diagnosis of hypersensitivity to food in children. Clin Allergy 7: 375, 1975.

    Google Scholar 

  21. May CD: Objective clinical and laboratory studies of immediate hypersensitivity reactions to food in children. J Allergy Clin Immunol 58: 500, 1976.

    Article  CAS  Google Scholar 

  22. Rowe AH:Food Allergy. Springfield, III: Charles C Thomas, 1972.

    Google Scholar 

  23. Biondi R: Personal communication.

    Google Scholar 

  24. Speen F:Food Allergy. Littleton, Mass: PSG Publishing, 1978.

    Google Scholar 

  25. Galant SP, Franz ML, Walker P,et al: A potential diagnostic method for food allergy: Clinical application and immunogenicity evaluation of an elemental diet.Am J Clin Nutr 30: 512, 1977.

    CAS  Google Scholar 

  26. Zlotlow MJ, Settipane GA: Allergic potential of food additives: A report of a case of tartrazine sensitivity without aspirin.Am J Clin Nutr 30: 1023, 1977.

    CAS  Google Scholar 

  27. Freier S, Berger H: Disodium cromoglycate in gastrointestinal protein intolerance. Lancet 2: 916, 1973.

    Google Scholar 

  28. Vaz GA, Tan L, Gerrard JW: Oral cromoglycate in treatment of adverse reactions to foods. Lancet 1: 1066, 1978.

    Article  CAS  Google Scholar 

  29. Brostoff J, Carini C, Wraith DG, et al: Production of IgE complexes by allergen challenge in atopic patients and the effect of sodium cromoglycate. Lancet 1: 1268, 1979.

    Article  CAS  Google Scholar 

  30. Paganelli R, Levinsky RJ, Brostoff J, et al: Immune complexes containing food proteins in normal and atopic subjects after oral challenge and effect of sodium cromoglycate on antigen absorption. Lancet 1: 1270, 1979.

    Article  CAS  Google Scholar 

  31. Kocoshis S, Gryboski JD: Use of cromolyn in combined gastrointestinal allergy. JAMA 242: 1169, 1979.

    Article  CAS  Google Scholar 

  32. Eastham EJ, Walker WA: Adverse effects of milk formula ingestion on the gastrointestinal tract. Gastroenterology 76: 365, 1979.

    CAS  Google Scholar 

  33. Parish WE: Detection of reaginic and short-term sensitizing anaphylactic or anaphylactoid antibodies to milk in sera of allergic and normal persons. Clin Allergy 1: 369, 1971.

    Article  CAS  Google Scholar 

  34. Jakobsson I, Lindberg T: Cow’s milk as a cause of infantile colic in breast-fed infants. Lancet 2: 438, 1978.

    Google Scholar 

  35. Grybowski JD: Gastrointestinal milk allergy in infants. Pediatrics 40: 354, 1967.

    Google Scholar 

  36. Kuitinen P, Visakorpi JK, Savilahti E, et al: Malabsorption syndrome with cow’s milk intolerance. Arch Dis Child 50: 351, 1975.

    Article  Google Scholar 

  37. Freier S, Kletter B, Gery I, et al: Intolerance to milk protein. Pediatrics 75: 623, 1969.

    Article  CAS  Google Scholar 

  38. Lubos MC, Gerrard JW, Buchan DJ: Disaccharidase activities in milk-sensitive and celiac patients. J Pediatr 70: 325, 1967.

    Article  CAS  Google Scholar 

  39. Baker AL, Rosenberg IH: Refractory sprue: Recovery after removal of nongluten dietary proteins. Ann Intern Med 89: 505, 1978.

    CAS  Google Scholar 

  40. Ureles AL, Alscibaja T, Lodico D, et al: Idiopathic eosinophilic infiltration of the gastrointestinal tract: diffuse and circumscribed. Am J Med 30: 899, 1961.

    Article  CAS  Google Scholar 

  41. Klein N, Hargove R, Sleisenger AM, et al: Eosinophilic gastroenteritis. Medicine 49: 299, 1970.

    Article  CAS  Google Scholar 

  42. Pitchumoni CS, Dearani AC, Burke AF, et al: Eosinophilic granuloma of the gastrointestinal tract. JAMA 211: 1180, 1970.

    Article  CAS  Google Scholar 

  43. Katz AJ, Goldman H, Grand RJ: Gastric mucosal biopsy in eosinophilic (allergic) gastroenteritis. Gastroenterology 73: 705, 1977.

    CAS  Google Scholar 

  44. Leinbach GE, Rubin CE: Eosinophilic gastroenteritis: A sample reaction to food allergens? Gastroenterology 59: 874, 1970.

    CAS  Google Scholar 

  45. Caldwell JH, Sharma HM, Hurtubise PE, et al: Eosinophilic gastroenteritis in extreme allergy. Gastroenterology 77: 560, 1979.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yale University School of Medicine, USA

    Martin H. Floch M.S., M.D., F.A.C.P. (Clinical Professor of Medicine, Chairman, Chief)

  2. Department of Medicine, Section of Gastroenterology and Nutrition, Norwalk Hospital, USA

    Martin H. Floch M.S., M.D., F.A.C.P. (Clinical Professor of Medicine, Chairman, Chief)

Authors
  1. Martin H. Floch M.S., M.D., F.A.C.P.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Publishing Corporation

About this chapter

Cite this chapter

Floch, M.H. (1981). Gastrointestinal Allergy and Food Hypersensitivity. In: Nutrition and Diet Therapy in Gastrointestinal Disease. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3791-1_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3791-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3793-5

  • Online ISBN: 978-1-4684-3791-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation