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Acquired Subclinical Diabetes Mellitus in Women Receiving Oral Contraceptive Agents

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Metabolic Effects of Gonadal Hormones and Contraceptive Steroids

Abstract

Although several conflicting observations have been reported concerning the effects of oral contraceptive agents on standard glucose tolerance tests, there is little doubt that the frequency of abnormal steroid-provocative glucose tolerance tests (GTT) is extraordinarily high among subjects on this regimen. diPaola and I co-workers (1) and Gershberg and associates (2) have observed independently that the incidence of positive steroid tests in: women receiving agents containing mestranol ranges from 45 to 85 percent or 10 to 20-fold greater than a general population. These findings imply that oral contraceptives induce an acquired form of subclinical diabetes mellitus. Possible etiologies of this defect and its reversibility after discontinuation of birth control medications are the subjects of this presentation.

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Authors and Affiliations

  1. Department of Medicine, Department of Obstetrics and Clinical Research Center, Marquette School of Medicine and Milwaukee County General Hospital, Milwaukee, Wisconsin, USA

    R. K. Kalkhoff, H. J. Kim & F. J. Stoddard

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  1. R. K. Kalkhoff
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  2. H. J. Kim
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  3. F. J. Stoddard
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Editor information

Editors and Affiliations

  1. Harvard Medical School, USA

    Hilton A. Salhanick (Professor of Obstetrics and Gynecology, Member) (Professor of Obstetrics and Gynecology, Member)

  2. Center for Population Studies, Harvard School of Public Health, USA

    Hilton A. Salhanick (Professor of Obstetrics and Gynecology, Member) (Professor of Obstetrics and Gynecology, Member)

  3. Washington University School of Medicine, USA

    David M. Kipnis (Professor of Medicine) (Professor of Medicine)

  4. College of Physicians and Surgeons, Columbia University, USA

    Raymond L. Vande Wiele (Professor of Obstetrics and Gynecology) (Professor of Obstetrics and Gynecology)

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© 1969 Plenum Press, New York

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Kalkhoff, R.K., Kim, H.J., Stoddard, F.J. (1969). Acquired Subclinical Diabetes Mellitus in Women Receiving Oral Contraceptive Agents. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_14

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  • DOI: https://doi.org/10.1007/978-1-4684-1782-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1784-5

  • Online ISBN: 978-1-4684-1782-1

  • eBook Packages: Springer Book Archive

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