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Insulin: Biochemical and Physiological Aspects

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Principles of Perinatal-Neonatal Metabolism

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Abstract

For more than half a century insulin has occupied the position as the most intensively studied mammalian hormone. This situation stems in part from its role as the preeminent anabolic hormone in mammals. The effort put into understanding the physiology and biochemistry of this peptide follows a rich scientific history that has come from its study. The demonstration by von Mering and Minkowski in 1889 that pancreatectomy in the dog resulted in a syndrome similar to diabetes mellitus1 eventually led to the discovery of insulin, which is credited to Banting and Best.2 A number of seminal discoveries that had an impact on all of biochemical physiology followed: quantification of the hormone by radioimmunoassay,3 sequencing of the peptide,4 complete synthesis of the hormone,5–6 determination of its x-ray crystallographic structure,7 and, most recently, cloning of the gene for insulin8 and synthesis of the recombinant protein for therapeutic use.9

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Authors
  1. Philip A. Gruppuso
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Editors and Affiliations

  1. Department of Pediatrics, Brown University Program in Medicine, Providence, RI, 02905, USA

    Richard M. Cowett MD (Professor of Pediatrics) (Professor of Pediatrics)

  2. Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, 02905, USA

    Richard M. Cowett MD (Professor of Pediatrics) (Professor of Pediatrics)

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© 1991 Springer-Verlag New York Inc.

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Gruppuso, P.A. (1991). Insulin: Biochemical and Physiological Aspects. In: Cowett, R.M. (eds) Principles of Perinatal-Neonatal Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0400-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-0400-5_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-0402-9

  • Online ISBN: 978-1-4684-0400-5

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