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Regulation of Muscle Contraction

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Cell and Muscle Motility

Abstract

The discovery of troponin (Ebashi and Kodama, 1965; cf. Ebashi et al., 1969) established the concept of regulation in muscle contraction and the term regulatory proteins (Maruyama and Ebashi, 1970). The absence of troponin or other specific regulatory proteins in molluscan striated muscle (Kendrick-Jones et al., 1970) suggested that the mode of regulation by Ca2 + is not as simple as it was expected to be. The complexity of Ca2 + regulation was further confirmed by research on regulatory mechanisms in smooth muscle (cf. Ebashi, 1979).

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References

  • Amphlett, G. W., Vanaman, T. C., and Perry, S. V., 1977, Effect of the troponin C-like protein from bovine brain (brain modulator protein) on the Mg2 + -stimulated ATPase of skeletal muscle actomyosin, FEB S Lett. 72: 163–168.

    Article  Google Scholar 

  • Chacko, S., Conti, M. A., and Adelstein, R. S., 1977, Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation, Proc. Natl. Acad. Sci. USA 74: 129–133.

    Google Scholar 

  • Cheung, W. Y., 1970, Cyclic 3’,5’-nucleotide phosphodiesterase, Demonstration of an activator, Biochem. Biophys. Res. Commun. 38: 533–538.

    Google Scholar 

  • Ebashi, S., 1979, Ca ion and muscle contraction, in: Advances in Pharmacology and Therapeutics, Vol. 3 ( J. C. Stoclet, ed.) pp. 81–98, Pergamon Press, Oxford.

    Google Scholar 

  • Ebashi, S., 1980, Regulation of muscle contraction (The Croonian Lecture 1979 ). Proc. Roy. Soc. London B 207: 259–286.

    Google Scholar 

  • Ebashi, S., and Ebashi, F., 1965, a-Actinin, a new structural protein from striated muscle, J. Biochem. 58: 712.

    Google Scholar 

  • Ebashi, S., and Kodama, A., 1965, A new protein factor promoting aggregation of tropomyosin, J. Biochem. 58: 107–108.

    PubMed  CAS  Google Scholar 

  • Ebashi, S., Endo, M., and Ohtsuki, I., 1969, Control of muscle contraction, Quart. Rev. Biophys. 2: 351–384.

    Google Scholar 

  • Ebashi, S., Nonomura, Y., Toyooka, T., and Katayama, E., 1976, Regulation of muscle contraction by the calcium-troponin-tropomyosin system, in: Calcium in Biological Systems. Symp. Soc. Exp. Biol., No. 30, pp. 349 - 360.

    Google Scholar 

  • Hasegawa, T., Takahashi, S., Hayashi, H., and Hatano, S., 1980, Fragmin: A calcium ion sensitive regulatory factor on the formation of actin filaments, Biochemistry 19: 2677–2683.

    Google Scholar 

  • Hirata, M., Mikawa, T., Nonomura, Y., and Ebashi, S., 1980, Ca2 + regulation in vascular smooth muscle, J. Biochem. 78: 369378.

    Google Scholar 

  • Kakiuchi, S., Yamazaki, R., and Nakajima, H., 1970, Properties of a heat stable phosphodiesterase activating factor isolated from brain extract, Proc. Japan Acad. 46: 587–592.

    Google Scholar 

  • Katayama, E., 1979, Interaction of troponin-I with troponin-T and its fragment, J. Biochem. 85: 1379–1381.

    PubMed  CAS  Google Scholar 

  • Kendrick-Jones, J., Lehman, W., Szent-Gyôrgyi, A. G., 1970, Regulation in molluscan muscles, J. Mol. Biol. 54: 313–326.

    Google Scholar 

  • Maruyama, K., and Ebashi, S., 1970, Regulatory proteins of muscle, in: The Physiology and Bio-chemistry of Muscle as a Food, Vol. 2, E. J. Briskey, R. G. Cassens, and B. B. March. The Univ. of Wisconsin Press, Madison, pp. 373–382.

    Google Scholar 

  • Maruyama, K., Kimura, S., Ishii, T., Kuroda, M., Ohashi, K., and Muramatsu, S., 1977, p- Actinin, a regulatory protein of muscle. Purification, characterization and function, J. Biochem. 81: 215–232.

    Google Scholar 

  • Mikawa, T., 1979, “Freezing” of the calcium-regulated structures of gizzard thin filaments by glutaraldehyde, J. Biochem. 85:879–881.

    Google Scholar 

  • Mikawa, T., 1980, Freezing of activated and depressed thin filaments of skeletal and smooth muscle, in: Muscle Contraction: Its Regulatory Mechanisms, (S. Ebashi, K. Maruyama and M. Endo) Japan Sci. Soc. Press, Tokyo pp. 347–357.

    Google Scholar 

  • Mikawa, T., Toyo-oka, T., Nonomura, Y., and Ebashi, S., 1977a, Essential factor of gizzard “Troponin” fracation, J. Biochem. 81: 273–275.

    PubMed  CAS  Google Scholar 

  • Mikawa, T., Nonomura, Y., and Ebashi, S., 1977b, Does phosphorylation of myosin light chain have direct relation to regulation in smooth muscle, J. Biochem. 82: 1789–1791.

    PubMed  CAS  Google Scholar 

  • Mikawa, T., Nonomura, Y., Hirata, M., Ebashi, S., and Kakiuchi, S., 1978, Involvement of an acidic protein in regulation of smooth muscle contraction by the tropomyosinleiotonin system, y. Biochem. 84: 1633–1636.

    CAS  Google Scholar 

  • Nagano, K., Miyamoto, S., Matsumura, M., and Ohtsuki, I., 1980, Possible formation of a triple- stranded coiled-coil region in tropomyosin-troponin T binding complex, J. Mol. Biol. 141: 217–222.

    Google Scholar 

  • Nakamura, S., Hashimoto, K., and Ohtsuki, I., 1981, Effect of chymotryptic troponin T subfragments on the Ca2 + sensitivity of superprecipitation,y. Biochem. 89: 1639–1641.

    CAS  Google Scholar 

  • Ohtsuki, I., 1980, Functional organization of the troponin-tropomyosin system, in: Muscle Contraction: Its Regulatory Mechanisms (S. Ebashi, K. Maruyama and M. Endo) Japan Sci. Soc. Press, Tokyo, pp. 237–249.

    Google Scholar 

  • Ohtsuki, I., Yamamoto, K., and Hashimoto, K., 1981, Effect of two C-terminal side chymotryptic troponin T subfragments on the Ca2 + sensitivity of superprecipitation and ATP ase activities of actomyosin, J. Biochem. 90: 259–261.

    PubMed  CAS  Google Scholar 

  • Perry, S. V., Cole, H. A., Head, J. F., and Wilson, F. J., 1972, Localization and mode of action of the inhibitory protein component of the troponin complex, Cold Spring Harbor Symposia, 32: 251–262.

    Google Scholar 

  • Tanokura, M., Tawada, Y., Onoyama, Y., Nakamura, S., and Ohtsuki, I., 1981, Primary structure of chymotryptic subfragments from rabbit skeletal troponin T,]. Biochem. 90: 263–265.

    CAS  Google Scholar 

  • Yin, H. L., Stossel, T. P., 1979, Control of cytoplasmic actin gelsol transformation by gelsolin, a calcium-dependent regulatory protein, Nature 281: 583–586.

    Article  PubMed  CAS  Google Scholar 

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© 1983 Plenum Press, New York

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Ebashi, S. (1983). Regulation of Muscle Contraction. In: Dowben, R.M., Shay, J.W. (eds) Cell and Muscle Motility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9296-9_4

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  • DOI: https://doi.org/10.1007/978-1-4615-9296-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9298-3

  • Online ISBN: 978-1-4615-9296-9

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