Progression of Early Diabetes

Abstract

The hereditary nature of diabetes has been amply established. Even though the nature of the genetic change is unknown, diabetes is a molecular disease; that is, a disease in which important cellular components are seriously impaired. Eventually, the activities or the products arising from the impairment find expression in various ways, finally culminating in the abnormalities of diabets. Insulin deficiency, one of the landmarks of overt, symptomatic diabetes, was investigated by us in patients at different stages of the disease, in an attempt to elucidate the pathophysiology of the progression of the disease.