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NAD Synthesis in Human Erytrhocytes: Study of Adenylyl Transferase Activities in Patients Bearing Purine Enzyme Disorders

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Purine and Pyrimidine Metabolism in Man VII

Abstract

The role of NAD in human erythrocytes is completely devoted to its function of cofactor in glicolysis and pentose shunt, mantaining the oxidoreductive state of the cells, since they lack mono- and poly- ADP ribosylations, and then its availability is absolutely necessary for cell survival.

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References

  1. J. Preiss and P. Handler, Intermediates in the synthesis of diphosphopyridine nucleotide from Nicotinic acid, J. Am.Chem. Soc. 79: 4246 (1957)

    Article  CAS  Google Scholar 

  2. I. G. Leder and P. Handler, Synthesis of Nicotinamide Mononucleotide by human erythrocytes in vitro, J. Biol. Chem., 189: 889 (1951)

    PubMed  CAS  Google Scholar 

  3. G. H. Hogeboom and W. C. Schneider, The synthesis of diphospho pyridine nucleotide by liver cell nuclei, J. Biol. Chem., 197: 611 (1952)

    PubMed  CAS  Google Scholar 

  4. P. Natalini, S. Ruggieri and G. Magni, Nicotinamide mononucleotide adenylyltransferase. Molecular and enzymatic properties of the homogeneous enzyme from Baker’s yeast. Biochemistry, 25: 3725 (1986)

    Article  CAS  PubMed  Google Scholar 

  5. S. Ruggieri, L. Gregori, P. Natalini, A. Vita, M. Emmanuelli, N. Raffaelli, and G. Magni, Evidence for an inhibitory effect exerted by yeast NMN adenylyltransferase on poly(ADP-ribose) polymerase activity, Biochemistry, 29: 2501 (1990)

    Article  CAS  PubMed  Google Scholar 

  6. M. E. Haines, I. R. Johnston, A. P. Mathias and D. Ridge, Synthesis of Nicotinamide Adenine Dinucleotide and poly (adenine diphosphate ribose) in various classes of rat nuclei, Biochem. J., 115: 881 (1969)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. T. Kato and O. H. Lowry, Distribution of enzymes between nucleous and cytoplasm of single nerve cell bodies, J. Biol. Chem., 248: 2044 (1973)

    PubMed  CAS  Google Scholar 

  8. M. Rechsteiner and V. Catanzarite, The biosynthesis and turnover of Nicotinamide Adenine Dinucleotide in enucleated culture cells, J. Cell. Physiol., 84: 409 (1974)

    Article  CAS  PubMed  Google Scholar 

  9. S. Sestini, P. Lusini, V. Micheli, M.L. Ceccuzzi and C. Ricci, Evidence for NMN Adenylyltransferase in human erythrocytes. Preliminary observations, Ital J. Biochem., 37: 63A, (1988)

    Google Scholar 

  10. V. Micheli, S. Sestini and C. Ricci, Purine and pyridine production in human erythrocytes, Arch. Biochem. Biophys. 244: 454 (1986)

    Article  CAS  Google Scholar 

  11. H. A. Simmonds, L. D. Fairbanks, G. S. Morris, D. R. Webster and E.H. Harley, Altered erythrocyte nucleotide patterns are characteristics of inherited disorders of purine or pyrimidine metabolism, Clin. Chim. Acta, 171: 197 (1988)

    Article  CAS  Google Scholar 

  12. V. Micheli, H. A. Simmonds and C. Ricci, Regulation of NicotinamideAdenine Dinucleotide synthesis in erythrocytes of patients with hypoxanthine-guanine phosphoribosyl transferase deficiency and a patient with phosphoribosyl pyrophosphate synthetase superactivity, Clin. Science, 78: 239 (1990)

    CAS  Google Scholar 

  13. M. Rocchigiani, S.Sestini, V. Micheli, M. Bari and H. A. Simmonds, NAD synthesis in human erythroçytes: determination of the activities of some enzymes, 7 International/ 3rd European Joint Symposium on PURINE AND PYRIMIDINE METABOLISM IN MAN, Bournemouth, 30th June-5th July

    Google Scholar 

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© 1991 Plenum Press, New York

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Sestini, S., Pescaglini, M., Magagnoli, C., Jacomelli, G., Rocchigiani, M., Simmonds, H.A. (1991). NAD Synthesis in Human Erytrhocytes: Study of Adenylyl Transferase Activities in Patients Bearing Purine Enzyme Disorders. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_71

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  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_71

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

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