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Soft Tissue Sarcomas: Present Achievements and Future Prospects pp 31–50Cite as

Molecular genetics of soft tissue sarcomas

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 91))

Abstract

During the past decade considerable progress has been made in elucidating the mechanisms underlying the development of human soft tissue sarcomas. It has been established that certain genetic disorders can predispose to the development of soft tissue sarcomas, and in many cases the individual genes containing the inherited mutation have been cloned and characterized. Cytogenetic studies have identified specific chromosomal translocations in certain types of soft tissue sarcoma, and most of the genes that become altered by these rearrangements have now been isolated. Progress has also been made in identifying genes that control the differentiation of some mesenchymal lineage (e.g., striated muscle). These recent developments are reviewed in this chapter, with particular emphasis being placed on (1) recent advances that have been made in understanding precisely how the genetic alteration found in soft tissue sarcomas may lead to tumor formation and (2) the potential use of genetic markers in tumor diagnosis and prognosis.

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  1. Colin S. Cooper
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  2. Paul Cornes
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Editors and Affiliations

  1. Department of Medical Oncology, Rotterdam Cancer Institute, Rotterdam, The Netherlands

    J. Verweij

  2. Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands

    H. M. Pinedo

  3. Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    H. D. Suit

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Cooper, C.S., Cornes, P. (1997). Molecular genetics of soft tissue sarcomas. In: Verweij, J., Pinedo, H.M., Suit, H.D. (eds) Soft Tissue Sarcomas: Present Achievements and Future Prospects. Cancer Treatment and Research, vol 91. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6121-7_3

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