Abstract
T helper cells are thought to be of importance in the pathogenesis of atopic dermatitis (AD)(1,2). Most patients with (AD) have elevated serum IgE levels(2–4). Allergens stimulate a certain population of T helper cells, the Th2-cells, that produce high amounts of interleukin-4 (IL-4), and relative low amounts of interferon-γ (IFN-γ)(5). IL-4 stimulates B-cells to IgE production(6). Bacteria and viruses induce the activation of Thl-cells, resulting in IFN-γ production and as a result we see a delayed hypersensitivity reaction (e.g.)(7)
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Van der Ploeg, I., Linder, M.T., Hägermark, Ö., Wahlgren, CF., Scheynius, A. (1996). Differential Gene Expression for Interleukin-13 and Other Cytokines in the Skin of Atopic Dermatitis Patients and Healthy Subjects. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_58
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DOI: https://doi.org/10.1007/978-1-4615-5855-2_58
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