Abstract
The glycopeptides are generally well tolerated and a low incidence of systemic side effects has been described (1). The adverse effects of vancomycin includes local phlebitis at the site of infusion (2,3). For this reason, we presumed that these solutions might be directly toxic for endothelial cells (EC), resulting in subsequent phlebitis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wood, M.J. (1996). The comparative efficacy and safety of teicoplanin and vancomycin. Journal of Antimicrobial Chemotherapy 37, 209–222.
Phillips, G. & Golledge, C. (1992). Vancomycin and teicoplanin: something old, something new. The Medical Journal of Australia 156, 53–57.
Downs, N. J., Neihart R. E., Dolezal, J. M. & Hodges, G. R. (1989). Mild nephrotoxicity associated with vancomycin use. Archivs of Internal Medicine 149(8), 1777–1781.
Forgue, S. T., Shyu, W. C., Gleason, C. R., Pittman, K. A. & Barbhaiya R. H. (1987). Pharmacokinetics of the novel cephalosporin cefepime (BMY—28142) in rats and monkeys. Antimicrobial Agents and Chemotherapy31(5), 799–804.
Griesmacher, A., Weigel, G., Windischbauer, A. & Mueller M. M. (1991). Purine metabolism in human endothelial cells. International Journal of Purine and Pyrimidine Research 2, 123–127.
Jaffe, E. A., Nachman, R. L., Becker, C. G. & Minck, C. R. (1973). Culture of human endothelial cells derived frem umbilical veins. Journal of Clinical Investigation 52, 2745–2756.
Haudenschild, C. C, Cotran, R. S., Gimbrone, M. A. & Folkman, J. (1975). Fine structure of vascular endothelium in culture. Journal of Ultrastructural Research 50, 22–34.
Jaffe, E. A., Hoyer, L. W. & Nachman, R. L. (1973). Synthesis of antihaemophilic factor antigen by human endothelial cells. Journal of Clinical Investigation 52, 2757–2763.
Schopf, G., Rumpold, H. & Mueller, M. M. (1986). Alterations of purine salvage pathways during differentiation of rat heart myoblasts towards myocytes. Biochimistry Biophysics Acta 884, 319–327.
Acevedo, A., Schoop, W., Schnell, A. & Toledo, L. (1990). Antibiotic treatment for diabetic foot. Advantages of intravenous regional route as alternative for systemic route. Rev. Med.Chil. 118, 881–888.
Partsch, H. (1990). Bier’s occlusion. An unjustly neglected therapeutic possibility in resistant tissue defects of the extremities. Acta Med. Austriaca 17, 35–39.
Schoop, W. & Acevedo, A. (1993). Antibiotic concentrations after intravenous and retrograde intravenous injections. Wiener Medizinische Wochenschrift 143, 199–200.
Farber, B. F. & Moellering, R. C. Jr. (1983). Retrospective study of the toxicity of preparations of van-comycin from 1974 to 1981. Antimicrobial Agents and Chemotherapy 23(1), 138–141.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Robibaro, B. et al. (1998). Influence of Glycopeptide Antibiotics on Purine Metabolism of Endothelial Cells. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_160
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5381-6_160
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7456-5
Online ISBN: 978-1-4615-5381-6
eBook Packages: Springer Book Archive