Abstract
Patients with Sjögren’s syndrome (SS) often complain of xerophthalmia and xerostomia. The loss of tear and saliva production in SS is secondary to lymphocytic infiltration and destruction of the lacrimal and salivary glands. Neither the reason for lymphocyte accumulation nor the mechanism for acinar destruction is known. In this and other autoimmune diseases, research has focused on specialized functions of immune cells and their products (e.g., cytokines). Particular attention has centered on the interaction between MHC molecules and T-cell receptors and on specific autoantibody and autoantigen interactions. This has led to a large body of information on immune repertoire, but offers few clues for treatment. Our recent investigations in SS have focused more on generalized functions that immune cells share with other cells. Chief among these is the important homeostatic mechanism called apoptosis, or programmed cell death (PCD).
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Talal, N., Nakabayashi, T., Letterio, J.J., Kong, L., Geiser, A.G., Dang, H. (1998). Cytokines may Prove Useful in the Treatment of Sjögrens Syndrome (SS) Dry Eye. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_135
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_135
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