Abstract
IL-6 is a multifunctional cytokine that exerts its activity via a receptor complex (IL-6R) composed of two subunits, an IL-6-binding α chain (gp80) and a signal transducing β chain (gp130) (1). The soluble form of the α subunit (sIL-6R) acts agonistically with IL-6 to enhance its activity both in vitro and in vivo (2,3). Moreover, the IL-6/sIL-6R complex displays a broader range of biological activities than IL-6 alone since it is capable of activating cells which possess gp130 but lack gp80 (2). In our pre-clinical studies, introduction of the IL-6 and sIL-6R genes into a weakly immunogenic murine melanoma cell line (B-78-H1) inhibited tumor growth potential and ability to metastasize concomitant with the stimulation of a potent, specific and long-lasting anti-melanoma immune response (3,4). The IL-6/sIL-6R complex was significantly better at inducing anti-melanoma activity than IL-6 alone. Analysis of tumor infiltrates demonstrated that IL-6/sIL-6R-secreting melanoma cells attracted CD8+ T cells and NK cells but not CD4+ T cells or dendritic cells (unpublished results).
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Abbreviations
- IL-6:
-
interleukin 6
- sIL-6R:
-
soluble interleukin 6 receptor
- MM:
-
malignant melanoma
- CD:
-
cell differentiation antigens
- CR:
-
complete response
- PR:
-
partial response
- SD:
-
stabile disease
- PD:
-
progression of the disease
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© 1998 Springer Science+Business Media New York
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Mackiewicz, A. et al. (1998). Immunogene Therapy of Human Melanoma. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_86
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DOI: https://doi.org/10.1007/978-1-4615-5357-1_86
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