Abstract
Multiple myeloma is a neoplastic disorder with a median overall survival duration of less than three years after conventional chemotherapy (1). High-dose therapy followed by allogeneic (2,3) or autologous stem-cell transplantation (4,5) has improved survival for subgroups of patients, but the overall survival for most patients has only been marginally improved. Although a small number of patients might have been cured with allogeneic transplantation, most patients will eventually relapse both following autologous and allogeneic transplants. New approaches to the treatment of patients with multiple myeloma are therefore warranted.
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References
Alexanian R, Haut R, Khan et al. Treatment for multiple myeloma: Combination chemotherapy with different melphalan dose regimens. JAMA 1969;208.1680–1685.
Gahrton G, Tura S, Ljungman P, Belanger C, Brandt L, Cavo M, Façon T, Granena A. Gore M, Gratwohl A, Löwenberg B, Nikoskelainen J, Reiffers JJ, Samson D, Verdonck L, Volin L. Allogeneic bone marrw transplantation in multiple myeloma. N Engl J Med 1991;325:1267–1273.
Gahrton G, Tura S, Ljungman P, Bladé J, Brandt L, Cavo M, Façon T, Gratwohl A, Hagenbeek A, Jacobs P, de Leurezi A, Van Lint M, Michallet M, Nikoskelainen J, Reiffers J, Samson D, Verdonck L, de Witte T, Volin L. Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma. J Clin Oncol 1995;13:13132–322
Björkstrand B, Goldstone AH, Ljungman P, Brandt L, Brunet S, Carlson K, Prentice HG, Cavo M, Samson D, de Laurenzi A, Verdonck LF, Proctor S, Ferrant A, Sierra J, Auzanneau G, Troussard X, Gravett P, Remes K, Gahrton G. Prognostic factors in autologous stem cell transplantation for multiple myeloma: An EBMT registry study. Leukemia and Lymphoma, 1994;15:265–272.
Attal M, Harousseau J-L, Stoppa A-M et al., for the Intergroupe Français du Myelome. N Engl J Med 1996;335:91–97.
Björkstrand B, Dilber MS, Smith CIE, Gahrton G, Xanthopoulos KG. Retroviral-mediated gene transfer into human myeloma cells. Br J Haematol 1994;88:325–331.
Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. BioTechniques 1989;7:980–988.
Björkstrand B, Ljungman P, Bird JM, Gahrton G. Double high-dose chemoradiotherapy with autologous stem cell transplantation can induce molecular remissions in multiple myeloma. Bone Marrow Transpl 1995;15:367–371.
Björkstrand B, Gahrton G, Dilber S, Ljungman P, Smith CIE, Xanthopoulos KG. Clinical Protocol. Retroviral-mediated gene transfer of CD34-enriched bone marrow and peripheral blood cells during autologous stem cell transplantation for multiple myeloma. Human Gene Therapy 1994;5:1279–1286.
Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992;256:1550.
Yoshida K, Kawami H, Yamaguchi Y, Kuniyasu H, Nishiyama H, Hirai T, Yanagihara K, Tahara E, Toge T. Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene. Cancer 1995;75:1467.
Dilber MS, Abedi MR, Björkstrand B, Christensson B, Gahrton G, Xanthopoulos KG, Smith CIE. Suicide gene therapy for plasma cell tumors. Blood 1996;88:2192–2200.
Dilber MS, Abedi MR, Christensson B, Björkstrand B, Kidder GM, Naus CCG, Gahrton G, Smith CIE. Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo. Cancer Res 1997;57:1523–1528.
Benda P, Lightbody J, Sato G, Levine L, Sweet W, Differentiated rat glial cell strain in tissue culture. Science (Washington DC) 1968:161:370–371.
Naus CC, Zhu D, Todd SD, Kidder GM. Characteristics of C6 glioma cells overexpressing a gap junction protein. Cell Mol Neurobiol 1992;12:163–175.
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Gahrton, G., Björkstrand, B., Dilber, M.S., Sundman-Engberg, B., Ljungman, P., Smith, C.I.E. (1998). Gene Marking and Gene Therapy in Multiple Myeloma. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_76
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DOI: https://doi.org/10.1007/978-1-4615-5357-1_76
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