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Prospects for the Metabolic Engineering of Bioactive Flavonoids and Related Phenylpropanoid Compounds

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Flavonoids in the Living System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 439))

Abstract

The successful engineering of complex metabolic pathways will require, in addition to availability of cloned genes and promoters, knowledge of the regulatory mechanisms that control metabolic flux into the pathway including post-translational phenomena such as metabolite channeling. We are interested in modifying pathways for the synthesis of isoflavonoids and other bioactive phenylpropanoid compounds in transgenic plants. We describe studies on flux control utilizing transgenic tobacco plants that under- and overexpress key biosynthetic enzymes, and outline experimental approaches for the molecular dissection of potential metabolic channels in the synthesis of antimicrobial flavonoid derivatives in alfalfa and other species.

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Authors and Affiliations

  1. Plant Biology Division, Samuel Roberts Noble Foundation, P.O. Box 2180, Ardmore, Oklahoma, 73402, USA

    Richard A. Dixon, Paul A. Howles, Xian-Zhi He & J. Thirupathi Reddy

  2. Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA

    Paul A. Howles & Chris Lamb

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  1. Richard A. Dixon
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  2. Paul A. Howles
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  3. Chris Lamb
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  4. Xian-Zhi He
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  5. J. Thirupathi Reddy
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Editors and Affiliations

  1. United States Department of Agriculture, Citrus and Subtropical Products Laboratory, P.O. Box 1909, 33883, Winter Haven, Florida, USA

    John A. Manthey

  2. State of Florida Department of Citrus, 700 Experiment Station Road, Lake Alfred, Florida, 33850, USA

    Béla S. Buslig

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Dixon, R.A., Howles, P.A., Lamb, C., He, XZ., Reddy, J.T. (1998). Prospects for the Metabolic Engineering of Bioactive Flavonoids and Related Phenylpropanoid Compounds. In: Manthey, J.A., Buslig, B.S. (eds) Flavonoids in the Living System. Advances in Experimental Medicine and Biology, vol 439. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5335-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-5335-9_5

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