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Different Expression of Prostaglandin-H Synthase Isozymes and Lipoxygenases During Multistage Carcinogenesis in Mouse Skin

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 400))

Abstract

An increasing body of epidemiologic data suggests the prostaglandin-H synthase (PGHS) pathway to arachidonic acid metabolisrii to be involved in human colon carcinogenesis. In addition, PGHS inhibitors were shown to reduce the tumor incidence in rat models of colon carcinogenesis (1). In the initiation-promotion model of mouse skin carcinogenesis inhibitors of both the PGHS and lipoxygenase (LOX) pathways were found to exhibit potent anti-promoting activities (2–5).

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References

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Authors and Affiliations

  1. Research Program Tumor Cell Regulation, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    G. Fürstenberger, K. Müller-Decker, K. Scholz, M. Löschke, W. D. Lehmann & F. Marks

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  1. G. Fürstenberger
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  2. K. Müller-Decker
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  3. K. Scholz
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  4. M. Löschke
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  5. W. D. Lehmann
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  6. F. Marks
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Free University Berlin, Berlin, Germany

    Santosh Nigam

  3. Vanderbilt University, Nashville, Tennessee, USA

    Lawrence J. Marnett

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© 1997 Springer Science+Business Media New York

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Fürstenberger, G., Müller-Decker, K., Scholz, K., Löschke, M., Lehmann, W.D., Marks, F. (1997). Different Expression of Prostaglandin-H Synthase Isozymes and Lipoxygenases During Multistage Carcinogenesis in Mouse Skin. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_56

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  • DOI: https://doi.org/10.1007/978-1-4615-5325-0_56

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7430-5

  • Online ISBN: 978-1-4615-5325-0

  • eBook Packages: Springer Book Archive

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