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Developmental Expression of the Mouse Mottled and Toxic Milk Genes

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Copper Transport and Its Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 448))

Abstract

In all living organisms, intracellular copper content is regulated and maintained by specialized cellular transport systems mediating copper uptake, intracellular compartmen-talization and utilization, and exit. In the face of copper deficiency, impaired catalysis by one or more of approximately thirty cuproenzymes leads to failure of growth, develop-ment, or survival of organisms or cells. On the other hand, copper excess may lead to pathology mediated by oxygen free radicals, with resultant damage to cellular components (Harris, 1991; Bull and Cox, 1994; Vulpe and Packman, 1995; Danks, 1995).

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Author information

Authors and Affiliations

  1. Department of Medicine, University of California-San Francisco, Third and Parnassus Avenues, San Francisco, California, 94143-0748, USA

    Yien-Ming Kuo & Jane Gitschier

  2. Division of Medical Genetics, Department of Pediatrics, University of California-San Francisco, Third and Parnassus Avenues, San Francisco, California, 94143-0748, USA

    Yien-Ming Kuo, Jane Gitschier & Seymour Packman

  3. Howard Hughes Medical Institute, University of California-San Francisco, Third and Parnassus Avenues, San Francisco, California, 94143-0748, USA

    Jane Gitschier

Authors
  1. Yien-Ming Kuo
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  2. Jane Gitschier
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  3. Seymour Packman
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Editor information

Editors and Affiliations

  1. University of Salerno, Salerno, Italy

    Arturo Leone

  2. The Murdoch Institute for Research into Birth Defects, Royal Children’s Hospital, Parkville, Australia

    Julian F. B. Mercer

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© 1999 Springer Science+Business Media New York

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Kuo, YM., Gitschier, J., Packman, S. (1999). Developmental Expression of the Mouse Mottled and Toxic Milk Genes. In: Leone, A., Mercer, J.F.B. (eds) Copper Transport and Its Disorders. Advances in Experimental Medicine and Biology, vol 448. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4859-1_9

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  • DOI: https://doi.org/10.1007/978-1-4615-4859-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7204-2

  • Online ISBN: 978-1-4615-4859-1

  • eBook Packages: Springer Book Archive

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