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Modulation of the Expression of the Cyclooxygenase 1 and 2 Genes in Rat Mammary Glands: Role of Hormonal Status and Dietary Fat

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 469))

Abstract

A role for ovarian and pituitary hormones in human breast cancer development has been suggested by observations such as the protective effects of a late age of menarche, an early age of menopause and first pregnancy and bilateral oopherectomy before the age 401,2. Similarly, completion of pregnancy and lactation or ovariectomy prior to carcinogen administration protects against mammary carcinogenesis in the rat3,4. Administration of a mammary carcinogen shortly before pregnancy enhances mammary tumor formation during the period of pregnancy and lactation compared to age-matched virgin controls5,6. Furthermore, treatment of rats with tamoxifen7,8 or 2-bromo-α-ergocryptine8, suppressers of estrogen and prolactin secretion respectively, at the time of, or shortly after carcinogen exposure, significantly inhibits tumorigenesis.

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Authors and Affiliations

  1. Laboratory of Pharmacogenetics, Clinical Pharmacology, Atlantic Veterinary College, 550 University Avenue Charlottetown, Prince Edward Island, Canada, C1A 4P3

    Alaa F. Badawi, Ahmed El-Sohemy, Laurie L. Stephen, Amit K. Ghoshal & Michael C. Archer

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  1. Alaa F. Badawi
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  2. Ahmed El-Sohemy
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  3. Laurie L. Stephen
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  4. Amit K. Ghoshal
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  5. Michael C. Archer
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Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California at San Diego, San Diego, California, USA

    Edward A. Dennis

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Badawi, A.F., El-Sohemy, A., Stephen, L.L., Ghoshal, A.K., Archer, M.C. (1999). Modulation of the Expression of the Cyclooxygenase 1 and 2 Genes in Rat Mammary Glands: Role of Hormonal Status and Dietary Fat. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_18

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  • DOI: https://doi.org/10.1007/978-1-4615-4793-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7171-7

  • Online ISBN: 978-1-4615-4793-8

  • eBook Packages: Springer Book Archive

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