Abstract
We have had a long-standing interest in the regulation of expression of mitochondrial aldehyde dehydrogenase (ALDH2). This enzyme has the lowest Km for acetaldehyde among many known aldehyde dehydrogenases, and a syndrome of genetic deficiency in ALD(Crabb et al., 1989) is known to markedly impair oxidation of acetaldehyde after consumption of ethanol (Enomoto et al., 1991). This impairment of acetaldehyde disposition is the cause of the Asian alcohol flush reaction and is very strongly protective against the development of alcoholism (Goedde et al., 1983; Harada et al., 1982; Thomas- son et., 1991). We reason that factors that alter the expression of the enzyme might also influence risk of alcoholism and have therefore studied the control of the ALDH2 gene, with particular attention to its expression in liver.
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Pinaire, J., Chou, WY., Stewart, M., Dipple, K., Crabb, D. (1999). Activity of the Human Aldehyde Dehydrogenase 2 Promoter Is Influenced by the Balance between Activation by Hepatocyte Nuclear Factor 4 and Repression by Perosixome Proliferator Activated Receptor δ, Chicken Ovalbumin Upstream Promoter-Transcription Factor, and Apolipoprotein Regulatory Protein-1. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_14
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DOI: https://doi.org/10.1007/978-1-4615-4735-8_14
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