Abstract
Overproduction of oxygen free radical is closely related to aging, cancer, inflammation, ischemia/reperfusion injury, and arteriosclerosis (Kerr et al., 1996). For protection against these free radical related diseases, many kinds of traditional Kampo medicine and traditional Chinese medicine, which are all crude drugs, have been used clinically (Otsuka, 1988). The data on their pharmacological mechanisms increased, but these data are not enough to be evaluated scientifically (Takahashi et al., 1993, Akamatsu et al., 1998). We found acteoside (ACT) and its derivatives, isolated from oriental medicine Phacellantus tubiflorus, as potent inhibitors of lipid peroxidation in mitochondria (Pan and Hori, 1994, Pan and Hori, 1996). We recently found that methyl α-D-glucoside (Me-Glc; Figure 1) enhanced the anti-peroxidative activity of acteoside in rat liver mitochondria (Sakamaki et al., 1996).
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Hori, H. et al. (1999). Enhancement Effect of Methyl α-D-Glucoside for Inhibitory Effects of Antioxidants on ADP/Fe2+-Induced Lipid Peroxidation in Rat Liver Mitochondria. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_48
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_48
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