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QSAR Based on Biological Microcalorimetry

On the study of the interaction between hydrazides and Escherichia con and Saccharomyces cerivisiae

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Molecular Modeling and Prediction of Bioactivity

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Abstract

QSAR studies may rely upon the correctness of quantitative measurement of drug potencies, that generally starts with in vitro screening.1–3 The screening of drugs using biological microcalorimetry 4–6 to derive quantitative biological potency values is a powerful tool for such studies. Yet, the lipophilicity measurement through partition coefficient, using the diffusion process of Taylor-Axis, log P TA, in the same cells used for the biological screening via biological microcalorimetry7 has been carried out. Thus, in this paper we show an established QSAR between hydrazide potencies against Escherichia colt and Saccharomyces cerivisiae and log P TA.

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References

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Authors and Affiliations

  1. Núcleo de Estudos em Química Medicinal-NEQUIM. Departamento de Química, Universidade Federal de Minas Gerais, Campus da Pampulha, 31270-901, Belo Horizonte, MG, Brazil

    M. L. C. Montanari & C. A. Montanari

  2. Chemical Laboratory, University of Kent at Canterbury, CT2 7NH, UK

    A. E. Beezer

Authors
  1. M. L. C. Montanari
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  2. A. E. Beezer
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  3. C. A. Montanari
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Editor information

Editors and Affiliations

  1. H. Lundbeck A/S, Valby, Denmark

    Klaus Gundertofte

  2. Royal Danish School of Pharmacy, Copenhagen, Denmark

    Flemming Steen Jørgensen

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© 2000 Springer Science+Business Media New York

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Montanari, M.L.C., Beezer, A.E., Montanari, C.A. (2000). QSAR Based on Biological Microcalorimetry. In: Gundertofte, K., Jørgensen, F.S. (eds) Molecular Modeling and Prediction of Bioactivity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4141-7_49

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  • DOI: https://doi.org/10.1007/978-1-4615-4141-7_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6857-1

  • Online ISBN: 978-1-4615-4141-7

  • eBook Packages: Springer Book Archive

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