Abstract
In the future treatment of diabetes mellitus by transplantation, the use of fetal pancreas (FP) rather than isolated adult pancreatic islets may have several advantages.2,3 Most importantly, FP has a generative capacity.41 However, the various factors necessary for engraftment, growth, maturation and function of FP grafts are poorly understood. In the quest for corroboration of findings by Ricordi and colleagues that islets transplanted with hepatocytes promoted hepatocyte survival,1 our pilot trials suggested that fetal liver (FL) exhibited a salutary effect on FP. Therefore, we investigated engraftment, histology and function of composite FP/FL grafts transplanted to 3 specific sites: intramural small bowel (ISB), renal subscapular (RSC), and intramuscular (IM). In anticipation of allograft studies, trials included cyclosporine treatment of recipients using doses that were islet toxic.
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Dafoe, D.C., Wang, X., Tafra, L., Berezniak, R., Lloyd, R.V. (1992). Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat. In: Vinik, A.I., Sirman, D.J. (eds) Pancreatic Islet Cell Regeneration and Growth. Advances in Experimental Medicine and Biology, vol 321. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3448-8_20
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DOI: https://doi.org/10.1007/978-1-4615-3448-8_20
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