Abstract
Adequate surgical resection, with or without radiotherapy, remains the primary potentially curative treatment of soft tissue sarcomas, as most patients present without clinically evident metastases. Unfortunately, metastases subsequently occur in up to half of these cases [1–4], despite adequate local control, and it is only with the elimination of hematogenously borne micrometastases that further improvements in survival will occur.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Enneking WF, Spanier SS, Malawer MM: The effect of the anatomic setting on the results of surgical procedures for soft parts sarcoma of the thigh. Cancer 47:1005–1023, 1981.
Russell WO, Kohen J, Enzinger F, Hajdu SI, Heise H, Martin RG, Meissner W, Miller WT, Schmitz RL, Suit HD: A clinical and pathological staging system for soft tissue sarcomas. Cancer 40:1562–1570, 1977.
Romsdahl MM, Lindberg RD, Martin RG: Patterns of failure after treatment of soft tissue sarcoma. Cancer Treat Symp 2:251–258, 1983.
Suit HD: Patterns of failure after treatment of sarcoma of soft tissue by radical surgery or by conservative surgery and radiation. Cancer Treat Symp 2:241–246, 1983.
Schable FM: Rationale for adjuvant chemotherapy. Cancer 39:2875–2882, 1977.
Eilber FR, Giuliano AE, Huth JF, Morton DL: A randomized prospective trial using postoperative chemotherapy (adriamycin) in high grade extremity soft-tissue sarcoma. Am J Clin Oncol (CCT) 11:39–45, 1988.
Wilson RE, Wood WC, Lerner HL, Antman K, Amato D, Corson JM, Proppe K, Harmon D, Carey R, Greenberger J, Suit H: Doxorubicin chemotherapy in the treatment of soft tissue sarcoma: Combined results of two randomized trials. Arch Surg 121:1354–1359, 1986.
Antman K, Ryan L, Borden E, Wood WC, Lerner HL, Corson JM, Carey R, Suit H, Balcerak S, Elias A, Baker L: Pooled results from three randomized adjuvant studies of doxorubicin versus observation in soft tissue sarcoma: 10 year results and review of literature. In: Salmon SE, ed. Adjuvant Therapy of Cancer VI. Philadelphia: WB Saunders, 1990, pp 529–543.
Baker LH: Adjuvant therapy for soft tissue sarcomas. In: Ryan JR, Baker LO, eds. Recent Concepts in Sarcoma Treatment. Dordecht: Kluwer Academic Publishers, 1988, pp 131–136.
Alvegard TA, Sigurdsson H, Mouridsen H, Solheim O, Unsgaard B, Ringborg U, Dahl O, Nordentoft AM, Blomqvist C, Rydholm A, Stener B, Ranstam J: Adjuvant chemotherapy with doxorubicin in high grade soft tissue sarcoma: A randomized trial of the Scandinavian Sarcoma Group. J Clin Oncol 7:1504–1513, 1989.
Gherlinzoni F, Bacci G, Picci P, Capanna R, Calderoni P, Lorenzi EG, Bernini M, Emiliani E, Barbieri E, Normand A, Campanacci M: A randomized trial for the treatment of high grade soft tissue sarcomas of the extremities: Preliminary observations. J Clin Oncol 4:552–558, 1986.
Picci P, Bacci G, Gherlinzoni F, Capanna R, Mercuri M, Ruggieri P, Baldini N, Avella M, Pignatti G, Manfrini M: Results of a randomized trial for a treatment for the treatment of localized soft tissue tumors (STS) of the extremities in adult patients. In: Ryan JR, Baker LO, eds. Recent Concepts in Sarcoma Treatment. Dordecht: Kluwer Academic Publishers, 1988, pp 144–148.
Gherlinzoni F, Pignatti G, Fontana M, Giunti A: Soft tissue sarcomas: The experience at the Istituto Ortopedico Rizzoli. Chir Organi Mov 75:150–154, 1990.
Sylvester R: Soft-tissue sarcomas of the extremities (letter). J Clin Oncol 5:321–322, 1987.
Lindberg RD, Murphy WK, Benjamin RS, Sinkovics JG, Martin RG, Romsdhal MM, Jesse RH, Russell HO: Adjuvant chemotherapy in the treatment of primary soft tissue sarcomas: A preliminary report. In: Management of Primary Bone and Soft Tissue Tumors. Chicago: Year Book Medical, 1986, pp 343–352.
Benjamin RS, Terjanian TO, Genoglio CJ, Barkley HT, Evans HC, Murphy WK, Martin RG: The importance of combination chemotherapy for adjuvant treatment of high risk patients with soft tissue sarcomas of the extremities. In: Salmon SE, ed. Adjuvant Therapy of Cancer V. New York: Grune & Stratton, 1987, pp 735–744.
Edmonson JH, Fleming TR, Ivans JC, Burgert O, Soule EH, O’Connell MJ, Sim FH, Ahmann DL: A randomized study of systemic chemotherapy following complete excision of non-osseous sarcomas. J Clin Oncol 2:1390–1396, 1984.
Rosenberg SA: Prospective randomized trials demonstrating the efficacy of adjuvant chemotherapy in adult patients with soft tissue sarcomas. Cancer Treat Rep 68:1067–1078, 1984.
Rosenberg SA: Adjuvant chemotherapy of adult patients with soft tissue sarcoma. In: De Vita V, Hellman S, Rosenberg S, eds. Important Advances in Oncology. Philadelphia: JB Lippincott, 1985, pp 273–294.
Baker AR, Chang AE, Glatstein E, Rosenberg SA: National Cancer Institute experience in the management of high grade extremity soft tissue sarcoma. In: Ryan JR, Baker LO, eds. Recent Concepts in Sarcoma Treatment. Dordrecht: Kluwer Academic Publishers, 1988, pp 123–130.
Chang AE, Kinsella T, Glatstein E, Baker AR, Sindelar WF, Lotze MT, Danforth DN, Sugarbaker PH, Lack EE, Steinberg SM, White DE, Rosenberg SA: Adjuvant chemotherapy for patients with high grade soft tissue sarcomas of the extremity. J Clin Oncol 6:1491–1500, 1988.
Glenn J, Kinsella T, Glatstein E, Tepper J, Baker A, Sugarbaker P, Sindelar W, Roth J, Brennan M, Costa J, Seipp C, Wesley R, Young RC, Rosenberg SA: A randomized, perspective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast and trunk. Cancer 55:1206–1214, 1985.
Bramwell V, Rouesse J, Steward W, Santoro A, Buesa J, Thomas D, Sylvester R: Reduced rate of local recurrence following CYVADIC chemotherapy in localized soft tissue sarcoma. Proc Am Soc Clin Oncol 8:320, 1989.
Bramwell V, Rouesse J, Steward W, Santoro A, Buesa J, Thomas D, Van Glabbeke M: Five year results of CYVADIC adjuvant chemotherapy for soft tissue sarcoma: An EORTC randomized trial (abstract). Eur J Cancer 27(Suppl 2):S161, 1991.
Bui NB, Maree D, Coindre JM, Bonchon F, Kantor G, Avril A, Ravaud A: First results of a perspective randomized study of CYVADIC adjuvant chemotherapy in adults with operable high risk soft tissue sarcoma. Proc Am Soc Clin Oncol 8:318, 1989.
Ravaud A, Bui NB, Coindre JM, Kantor G, Stockle E, Lagarde P, Becouarn Y, Chauvergne J, Bonichon F, Maree D: Adjuvant chemotherapy with Cyvadic in high risk soft tissue sarcoma: A randomized prospective trial. In: Salmon SE, ed. Adjuvant Therapy of Cancer VI. Philadelphia: WB Saunders, 1990, pp 556–566.
Antman K, Ryan L, Borden E, Wood W, Lerner H, Corson J, Carey R, Suit H, Balcerak S, Sherman M, Baker L: Pooled results from three randomized adjuvant studies of doxorubicin versus observation in soft tissue sarcoma: 10 year results. Proc Am Soc Clin Oncol 9:311, 1990.
L’abbe KA, Detsky AS, O’Rourke K: Meta-analysis in clinical research. Ann Intern Med 107:224–233, 1987.
Omura GA, Blessing JA, Major F, Lifshitz S, Ehrlich CE, Mangan C, Beecham J, Park R, Silverberg S: A randomized clinical trial of adjuvant adriamycin in uterine sarcomas: A Gynecologic Oncology Group Study. J Clin Oncol 3:1240–1245, 1985.
Jones GW, Chouinard E, Patel M: Adjuvant Adriamycin (doxorubicin) in adult patients with soft-tissue sarcomas: A systematic overview and quantitative meta-analysis (abstract). Clin Invest Med 14(Suppl 19):A772, 1991.
Dresdale A, Bonow RO, Wesley R, Palmeri ST, Barr L, Mathison D, D’Angelo T, Rosenberg SA: Prospective evaluation of doxorubicin-induced cardiomyopathy resulting from post-surgical adjuvant treatment of patients with soft tissue sarcomas. Cancer 52:51–60, 1983.
Ettinghausen SE, Bonow RO, Palmeri ST, Seipp CA, Steinberg SM, White DE, Rosenberg SA: Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft tissue sarcomas. Arch Surg 121:1445–1491, 1986.
Harris J, Das Gupta T, Vogelzang N, Badrinath K, Bonomi P, Deser R, Locker G, Blough R, Johnson C: Treatment of soft tissue sarcoma with fibroblast interferon (beta-interferon): An American Cancer Society/Illinois Cancer Council Study. Cancer Treat Rep 70:293–294, 1986.
Fidler IJ: Optimization and limitations of systemic treatment of murine melanoma metastases with liposomes containing muramyl tripeptide phosphatidylethanolamine. Cancer Immunol Immunother 21:169–173, 1986.
Fidler IJ, Jessup JM, Fogler WE, Staerkel R, Mazumder A: Activation of tumoricidal properties in peripheral blood monocytes of patients with colorectal carcinoma. Cancer Res 46:994–998, 1986.
Jarowenkod G, Sigler SC, Pellis NR: Muramyl tripeptide: An effective immunotherapy in the surgical setting for pediatric abdominal neoplasms. J Pediatr Surg 22:497–500, 1987.
MacEwen EG, Kurzman ID, Rosenthal RC, Smith BW, Manley PA, Roush JK, Howard PE: Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide. J Natl Cancer Inst 31:925–928, 1989.
Murray JL, Kleinerman ES, Cunningham JE, Tatom JR, Andrejcio K, Lepe-Zuniga J, Lamki LM, Rosenblum MG, Frost H, Gutterman JU, Fidler IJ, Krakoff IH: Phase I trial of liposome muramyl tripeptide phosphatidylethanolamine in cancer patients. J Clin Oncol 7:1915–1925, 1989.
Urba WJ, Hartmann LC, Longo DL, Steis RG, Smith JW, Kedar I, Creekmore S, Sznol M, Conlon K, Kopp WC, Huber C, Herold M, Alvord WG, Snow S, Clark JW: Phase I and immunomodulatory study of muramyl peptide, muramyl tripeptide phosphatidylethanolamine. Cancer Res 50:2979–2986, 1990.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mertens, W.C., Bramwell, V.H. (1993). Adjuvant chemotherapy of soft tissue sarcomas. In: Verweij, J., Pinedo, H.M., Suit, H.D. (eds) Multidisciplinary Treatment of Soft Tissue Sarcomas. Cancer Treatment and Research, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3082-4_8
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3082-4_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6346-0
Online ISBN: 978-1-4615-3082-4
eBook Packages: Springer Book Archive