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Detection and Quantification of GTP Cyclohydrolase I m RNA

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Chemistry and Biology of Pteridines and Folates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 338))

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Abstract

There is accumulating evidence that H4biopterin is synthesized in cells which do not depend on H4biopterin cofactor but undergo cytokine directed proliferation1. In this case, H4biopterin has a function which is apparently unrelated to its known cofactor role. It modulates the clonal expansion of T cells2–4 and the proliferation of erythroid cells5,6. Closer analysis has shown that it enhances the affinity of the IL-2 receptor complex to its ligand and subsequently affects various aspects of signal transmission7.

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Author information

Authors and Affiliations

  1. GSF-Institut für Klinische Molekularbiologie und Tumorgenetik, Marchioninistraße 25, D-8000, München 70, Germany

    Markus Gütlich, Karin Schott & Irmgard Ziegler

  2. GSF-Institut für Säugetiergenetik, Ingolstädter Landstr. 1, D-8042, Neuherberg, Germany

    Thomas Werner

  3. Lehrstuhl für Organische Chemie und Biochemie, Techinsche Universität München, Lichtenbergstr. 4, D-8046, Garching, Germany

    Adelbert Bacher

Authors
  1. Markus Gütlich
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  2. Karin Schott
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  3. Thomas Werner
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  4. Adelbert Bacher
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  5. Irmgard Ziegler
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Editor information

Editors and Affiliations

  1. Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    June E. Ayling

  2. Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    M. Gopal Nair

  3. College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    Charles M. Baugh

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© 1993 Springer Science+Business Media New York

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Gütlich, M., Schott, K., Werner, T., Bacher, A., Ziegler, I. (1993). Detection and Quantification of GTP Cyclohydrolase I m RNA. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_32

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  • DOI: https://doi.org/10.1007/978-1-4615-2960-6_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6287-6

  • Online ISBN: 978-1-4615-2960-6

  • eBook Packages: Springer Book Archive

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