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Metabolic Role of Aldehyde Dehydrogenase

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Enzymology and Molecular Biology of Carbonyl Metabolism 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 328))

Abstract

Aldehyde dehydrogenase (EC 1.2.1.3), an enzyme with a broad substrate specificity and low Km values for short chain aliphatic aldehydes utilizes NAD as coenzyme, is universally distributed in mammalian livers and also at lower concentrations in other organs. The enzyme is a homotetramer of MW of ca. 220,000 (see review by Pietruszko, 1989). Because of its broad substrate specificity, it is frequently considered to be an enzyme of detoxication which functions in the organisms in oxidation of toxic aldehydes ingested in foodstuffs (see review by Jakoby and Ziegler, 1990). Metabolism of ethanol derived acetaldehyde, which is known to be catalyzed by this enzyme (Parrilla et al., 1974) is an example of detoxication role of aldehyde dehydrogenase. In the human liver the enzyme occurs as three known isozymes, El, E2 and E3; other isozymes not yet identified may exist.

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Author information

Authors and Affiliations

  1. Institute of General Food Chemistry, Technical University of Lodz, Lodz, Poland

    Wojciech Ambroziak

  2. Center of Alcohol Studies, Rutgers University, Piscataway, New Jersey, 08855-0969, USA

    Regina Pietruszko

Authors
  1. Wojciech Ambroziak
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  2. Regina Pietruszko
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Editor information

Editors and Affiliations

  1. Purdue University, West Lafayette, Indiana, USA

    Henry Weiner

  2. Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana, USA

    David W. Crabb

  3. Queens University, Kingston, Ontario, Canada

    T. Geoffrey Flynn

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© 1993 Springer Science+Business Media New York

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Ambroziak, W., Pietruszko, R. (1993). Metabolic Role of Aldehyde Dehydrogenase. In: Weiner, H., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 4. Advances in Experimental Medicine and Biology, vol 328. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2904-0_2

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  • DOI: https://doi.org/10.1007/978-1-4615-2904-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6259-3

  • Online ISBN: 978-1-4615-2904-0

  • eBook Packages: Springer Book Archive

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