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Neuroendocrine characteristics in malignant lung tumors: Implications for diagnosis, treatment, and prognosis

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Lung Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 72))

Abstract

Twenty years ago, Pearse identified a group of endocrine cells sharing multiple morphological and biochemical features. He named them APUD cells (Amine Precurser Uptake and Decarboxylation) because of their amine-handling properties, one of their main functions being their ability to take up and decarboxylate relatively simple amino precursor substances, such as dihydroxyphenylanaline (DOPA) and 5-hydroxytryptamine (5-HT), thus producing biogenic amines [1]. Today, these cells are known as neuro-endocrine (NE) cells and the APUD system as the Dispersed Neuroendocrine System (DNS), currently consisting of more than 40 different cell types.

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Authors
  1. Thomas Senderovitz
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  2. Birgit G. Skov
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  3. Fred R. Hirsch
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Editor information

Editors and Affiliations

  1. Department of Oncology 5074, Rigshospitalet, 9 Blegdamsvej, DK-2100, Copenhagen, Denmark

    Heine H. Hansen

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© 1994 Springer Science+Business Media New York

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Senderovitz, T., Skov, B.G., Hirsch, F.R. (1994). Neuroendocrine characteristics in malignant lung tumors: Implications for diagnosis, treatment, and prognosis. In: Hansen, H.H. (eds) Lung Cancer. Cancer Treatment and Research, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2630-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-2630-8_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6128-2

  • Online ISBN: 978-1-4615-2630-8

  • eBook Packages: Springer Book Archive

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