Abstract
Cells may take up iron by a variety of routes, depending upon the cell type and the environment. The most studied and best characterised uptake mechanism involves acquisition of transferrin-bound iron. This process, which is discussed in detail elsewhere in this volume, involves binding of Fe-transferrin to membrane transferrin receptors and endocytosis of the Fe-transferrin-transferrin receptor complex (Dautry-Varsat, 1986). The distinctive feature of this system is that iron can itself regulate uptake through binding of the iron-responsive element-binding protein (IRE-BP) to the transferrin receptor mRNA (Kühn and Hentze, 1992). In most cases uptake of transferrin-bound iron occurs in response to the metabolic needs of the cell. These principally involve haem synthesis in erythroid precursors, or events related to other activities such as cell proliferation in nonerythroid cells.
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© 1994 Springer Science+Business Media New York
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Brock, J.H., Djeha, A., Ismail, M., Oria, R., Sinclair, R.H. (1994). Cellular Responses to Iron and Iron Compounds. In: Hershko, C., Konijn, A.M., Aisen, P. (eds) Progress in Iron Research. Advances in Experimental Medicine and Biology, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2554-7_10
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DOI: https://doi.org/10.1007/978-1-4615-2554-7_10
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