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Quantitative Cellular Evaluation of Conjunctival Squamous Metaplasia in the Dry Eye Patient

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 350))

Abstract

Cytology can be used to evaluate ocular surface changes in patients with dry eye. For example, impression cytology of the conjunctiva has been utilized as a diagnostic tool to examine for possible alterations in both the number of goblet cells and appearance of squamous cells1,2. However, although this cytologic technique detects goblet cells and keratinized cells effectively, it is sometimes difficult to observe their morphologic details and to evaluate them quantitatively, because of the overlapping of cells. For the objective assessment of dry eye conditions, it is necessary to accurately visualize and quantitate ocular surface alterations at the cellular level.

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References

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Women’s Medical College, Tokyo, Japan

    Etsuko Takamura, Hiroko Takano, Keiko Yoshino & Kazumi Negoro

  2. Department of Ophthalmology, Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  3. Department of Cytopathology, Saiseikai Shiga Hospital, Shiga, Japan

    Tadao Kobayashi

Authors
  1. Etsuko Takamura
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  2. Hiroko Takano
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  3. Keiko Yoshino
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  4. Kazumi Negoro
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  5. Kazuo Tsubota
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  6. Tadao Kobayashi
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute and Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan

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© 1994 Springer Science+Business Media New York

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Takamura, E., Takano, H., Yoshino, K., Negoro, K., Tsubota, K., Kobayashi, T. (1994). Quantitative Cellular Evaluation of Conjunctival Squamous Metaplasia in the Dry Eye Patient. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_90

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  • DOI: https://doi.org/10.1007/978-1-4615-2417-5_90

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6025-4

  • Online ISBN: 978-1-4615-2417-5

  • eBook Packages: Springer Book Archive

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