Abstract
Eye closure induces many changes in the precorneal environment. These environmental changes have been implicated as contributing factors in the development of acute and chronic changes in the morphology and physiology of the anterior eye. Recent research has suggested that eye closure in association with hydrogel contact lens extended wear (EW) is a major risk factor for acute ocular inflammation, culture-negative peripheral ulcers and serious corneal infections.
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Holden, B.A., Tan, K.O., Sack, R.A. (1994). The Closed-Eye Challenge. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_74
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_74
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