Abstract
Major histocompatibility (MHC) class II molecules present peptides derived from exogenous antigens to CD4+ T lymphocytes (reviewed 1,2,3). The MHC class II molecule is a heterodimer of two transmembrane subunits, an α chain (33 kDa) and β chain (29 kDa), both encoded in the MHC region4. The ends of the peptide-binding groove of MHC class II molecules are open so peptides can extend out. As a result, MHC class II-associated peptides have a length varying between 12–24 amino acids residues5. MHC class II molecules are primarily expressed on antigen presenting cells (APC), such as B cells, macrophages and dendritic cells (DC).
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Ossevoort, M.A., Kleijmeer, M.J., Nijman, H.W., Geuze, H.J., Kast, W.M., Melief, C.J.M. (1995). Functional and Ultrastructural Aspects of Antigen Processing by Dendritic Cells. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_51
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_51
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