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Anti-Inflammatory Capacities of Human Milk: Lactoferrin and Secretory IgA Inhibit Endotoxin-Induced Cytokine Release

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Advances in Mucosal Immunology

Abstract

To study various immunological functions, passive transfer experiments are often crucial, both for humoral and cellular activities. They can readily be performed in animals, but less commonly in man. There is, however, one situation which provides good possibilities to study passive transfer of mucosal immunity in man: the role of maternal milk for the protection of the breast fed infant. Very strong effects have been found, so that the risk of dying of diarrhoea for a non-breast fed baby in a poor country is 25 times that of an exclusively breast fed.1

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Hanson, L.Å., Mattsby-Baltzer, I., Engberg, I., Roseanu, A., Elverfors, J., Motas, C. (1995). Anti-Inflammatory Capacities of Human Milk: Lactoferrin and Secretory IgA Inhibit Endotoxin-Induced Cytokine Release. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_141

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  • DOI: https://doi.org/10.1007/978-1-4615-1941-6_141

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5796-4

  • Online ISBN: 978-1-4615-1941-6

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