Abstract
The diverse pharmacological action of serotonin (5-HT) has been the subject of intense study since its identification in 1936.1 The diversity of actions include activation or inhibition of smooth and cardiac muscle, exocrine and endocrine glands, cells of the hematopoietic and immune systems, as well as central and peripheral neurons.2,3 The results of these investigations have led to the identification of at least 12 different 5-HT receptors based on operational (functional, antagonism, location), transductional (G-protein, ion channel), and structural (gene sequence, chromosomal location) criteria.4 Based on these criteria, 5-HT receptors have been grouped into 5 types, namely 5-HT1 5-HT2, 5-HT3, 5-HT4, and 5-HT5 receptors.5,6
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Wong, E.H.F., Bonhaus, D.W., Eglen, R.M. (1995). The Identification of Heterogeneity of 5-HT3 Receptors with [3H]RS-42358-197. In: Tang, L.C., Tang, S.J. (eds) Neurochemistry in Clinical Application. Advances in Experimental Medicine and Biology, vol 363. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1857-0_12
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