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Checkpoints in the cell cycle from a modeler’s perspective

  • Chapter
Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The cell division cycle is a complex process by which cells grow and divide into two viable daughter cells. So that mistakes are not made in this crucial replication process, cells stop at one or more “checkpoints” in the cycle to query their internal state and external conditions, before proceeding to the next stage of the cycle. In this paper we study some simple mathematical models of cell cycle arrest in G1 (“Start”) and G2. Our models help to relate the molecular mechanisms of these checkpoints with physiological properties of the cell cycle.

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Author information

Authors and Affiliations

  1. Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061-0406, USA

    John J. Tyson, Bela Novak, Kathy Chen & John Val

  2. Department of Agricultural and Chemical Technology, Technical University of Budapest, Gellert Ter 4, H-1521, Budapest, Hungary

    Bela Novak

Authors
  1. John J. Tyson
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  2. Bela Novak
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  3. Kathy Chen
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  4. John Val
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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© 1995 Springer Science+Business Media New York

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Tyson, J.J., Novak, B., Chen, K., Val, J. (1995). Checkpoints in the cell cycle from a modeler’s perspective. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_1

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  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5731-5

  • Online ISBN: 978-1-4615-1809-9

  • eBook Packages: Springer Book Archive

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