Abstract
Several factors affect MHV infection in mice (Table 1). They can be classified into two groups, viral factors and host factors. Although JHMV induces a fatal encephalitis in mice after intracerebral infection, it does a mild hepatitis when it is inoculated intraperitoneally. On the other hand, host genetic factor is a critical determinant. Among MHV researchers, it is well known that SJL mice are relatively resistant to intracerebral infection with JHMV (Stohlman & Frelinger 1978). In addition, the immune system is one of the key players that determine MHV infection in mice.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Arnheiter, H., 1980, Primary monolayer culture of adult mouse hepatocytes— a model for the study of hepatotropic viruses. Arch. Virol. 63:11–22.
Kyuwa, S., Machii, K., and Shibata, S., 1996, Role of CD4+ and CD8+ T cells in mouse hepatitis virus infection in mice. Exp. Anim. 45:81–83.
Kyuwa, S., Tagawa, Y., Shibata, S., Doi, K., Machii, K., and Iwakura, Y., 1998, Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon. J. Virol. 72:9286–9290.
Olsen, C. W., 1993, A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination. Vet Microbiol 36:1–37.
Stohlman, S. A., and Frelinger, J. A., 1978, Resistance to fatal central nervous system disease by mouse hepatitis virus, strain JHM. I. Genetic analysis, Immunogenetics 6:277–281.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kyuwa, S. et al. (2001). The Severity of Hepatic Lesion after Intraperitoneal JHMV Infection in IFN-gamma Deficient Mice is Parallel to Viral Replication in Hepatocytes in Vitro . In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1325-4_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5498-7
Online ISBN: 978-1-4615-1325-4
eBook Packages: Springer Book Archive