Abstract
Human coronaviruses (HCoV) cause upper respiratory tract infections manifested by symptoms of the common cold including rhinitis, tussis, fever, headache and myalgia (Hruskova et al 1990). HCoV respiratory illness is primarily virus-mediated; immunologic events have not been postulated to play a role (Makela et al 1998). Evidence showing the presence of viral genome in spinal fluid and brain suggests that HCoV may play an etiologic role in multiple sclerosis (Stewart et al 1992, Cristallo et al 1997). However, the pathogenesis of HCoV infections is poorly understood. In human embryonic tracheal organ cultures, HCoV causes a slow patchy destruction of the ciliated epithelial cells and in respiratory epithelial tissue cultures, the cytopathic effect is subtle, evident only by vacuolization and spindling.
Chapter PDF
Similar content being viewed by others
Keywords
- Multiple Sclerosis Patient
- Internal Ribosome Entry Site
- Common Cold
- Mouse Hepatitis Virus
- Ciliated Epithelial Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
An, S., Chen, C-J., Xin, Y., Leibowitz, J. L. and S. Makino. 1999. Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer. J. Virol. 73: 7853–7859.
Arbour, N., Côté, G., Lachance, C., Tardieu, M., Cashman, N. R., and P. J. Talbot. 1999. Acute and Persistent Infection of Human Neural Cell Lines by Human Coronavirus OC43. J. Virol. 73: 3338–3350.
Bonati, A., Albertini, R., Garau, D., Pinelli, S., Lunghi, P., Almici, C., Carlo-Stella, C., Rizzoli, V., and P. Dall’aglio. 1996. BCL2 oncogene protein expression in human hematopoietic precursors during fetal life. Exp.Hematol. 24:459–465.
Collins, A. R. and O. Sorensen. 1986 Regulation of viral persistence in human glioblastoma and rhabdomyosarcoma cells infected with Coronavirus OC43. Microbial Path. 1: 573–583.
Cristallo, A., Gambaro, F., Biamonte G., Ferrante, P., Battaglia, M. and P. M. Cereda. 1997. Human Coronavirus polyadenylated RNA sequences in cerebrospinal fluid from multiple sclerosis patients. New Microb. 20: 105–114.
Eleouet, J., Chilmonczy, S., Besnardeau, L., and H. Laude. 1998. Transmissible gastroenteritis Coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway. J. Virol. 66: 4918–4924.
Fischer, F., Stegen, CR., Masters, P. S. and W. A. Samsonoff. 1998. Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in Coronavirus assembly. J. Virol. 72: 7885–7894.
Hruskova, J., Heinz, F., Svandova, E. and S. Pennigerova. 1990. Antibodies to human coroanviruses 229e and OC43 in the population of C. R. Arch. Virol. 34: 346–352.
Jan, J. and D. E. Griffin. 1999. Induction of apoptosis by Sindbis virus occurs at cell entry and does not require virus replication. J. Virol. 73: 10296–10302.
Jendrach, M., Theil. V., and S. Siddell. 1999. Characterization of an internal ribosome entry site within mRNA5 of murine hepatitis virus. Arch. Virol. 144: 921–933.
Makela, M. J., Puhakka, T., Ruuskanen, O., Leinonen, L. M., Saikku, P., Kimpimaki, M., Blomqvist, S., Hyypia, T. and P. Arstila. 1998. Viruses and bacteria in the etiology of the common cold. J. Clin. Microbiol. 36: 539–542.
Stewart, J. N., Mounir, S. and PJ. Talbot. 1992. Human Coronavirus gene expression in the brains of multiple sclerosis patients. Virol. 191:502–505.
Varsano, S., Frolkis, I., and D. Ophir. 1995. Expression and distribution of cell-membrane complement regulatory glycoproteins along the human respiratory tract. Am. J. Respir. Crit. Care Med. 152: 1087–1093.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Collins, A.R. (2001). Induction of Apoptosis in MRC-5, Diploid Human Fetal Lung Cells after Infection with Human Coronavirus OC43. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_100
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1325-4_100
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5498-7
Online ISBN: 978-1-4615-1325-4
eBook Packages: Springer Book Archive